RECENT ADVANCES IN GASTRO RETENTIVE DRUG DELIVERY SYSTEM: A REVIEW
Several controlled oral drug delivery systems with prolonged gastric residence time have been reported recently. Gastro retentive drug delivery system is an approach to prolong gastric residence time, thereby targeting site-specific drug release in upper gastro intestinal tract improving the oral sustained delivery of drug that have an absorption window in a particular region of the gastrointestinal tract. These systems help in continuously releasing the drug before it reaches the absorption window, thus ensuring optimal bioavailability. Various approaches for gastric retention are Floating system, Swelling and expanding system, Bioadhesive systems, Modified-shape systems, High density systems etc.
Chein YW. Novel Drug Delivery Systems, 2nd edition, Marcel Dekker, New York, 2005, 157-63.
Kumar R, Philip A. Gastroretentive Dosage forms for prolonging gastric residence time. Int J Pharm Med 2007; 21 (2): 157-71.
Vyas SP, Khar RK. Controlled Drug Delivery: Concept and Advances 1st ed. Vallabh Prakashan; Delhi; 2002.
Smriti K, Dheeraj G, Rakesh P, Ahmad FJ. Recent Advances in Floating Drug Delivery System. The Ind Pharmacist Sep 2007; 1724.
Chatterjee CC. Human Physiology. Vol I, Medical Allied Agency; Kolkata; 2004; 435-38.
Waugh A, Grand A. Ross and Wilson Anatomy and Physiology: In Health and Illness. 10th edi, Churchill Livinstone Elsevier; Edinburgh; 2006; 293-95.
Brahmankar DM, Jaiswal SB. Biopharmaceutics and Pharmacokinetics.
Kale RD, Tayade PT. A Multiple Unit Drug Delivery System of Pyroxicam Using Eudragit Polymer. India J Pharm Sci 2007; 69 (1) : 120-23.
El-Kamel AH, Sokar MS, Al Gamal SS, Naggar VF. Preparation and Evaluation of Ketoprofen Floating Oral Delivery System. Int J Pharmaceutics 2001 ; 220: 13-21.
Ali J, Arora S, Ahuja A, Babbar AK, Sharma RK, Khar RK, et al. Formulatin and development of hydrodynemically balanced system for metformin; In vitro and in vivo evaluation. Eur J of Pharmaceutics and Biopharmaceutics 2007; 67:
Choia BY, Park HJ, H wangb SJ, Parkc JB. Preparation of alginate Beads for floating Drug Delivery System: Effects of CO2 Gas â€“ Forming Agents. Int J Pharmaceutics 2002 Jan.
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