HISTOPATHOLOGICAL STUDIES OF LIVER FUNCTION IN RATS FED ON GINGER LILLY CORM MEAL
The effect of feeding Gladiolus unguiculata corm on a few liver function markers were evaluated in this study using albino Wistar rats. Twenty rats were randomly divided into four groups of five rats each. Various concentration of G. unguiculata formulations were fed to the test groups excluding the negative control which received normal feed for the 28 days of analysis. At the end of the feeding period the levels of the serum liver function markers of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP) and Protein were determined. Mean serum liver function markers were all increased when compared with the control with only AST liver marker deviating. The ALT activity increased from 36.0 + 3.16 in the control to 38.0 + 3.16 in 20%. The AST significantly increased (p<0.05) from 66.0 + 3.16 in the 20% to 88.0 + 3.16 in the control group. ALP significantly increased from 47.0 +3.16 in the control group to 56.0 + 3.16 in 20%. Protein also increased from 7.0 +0.316 in the control group to 7.8 +0.316 in 20%. The results emanating from this study suggest that Gladiolus unguiculata corm formulations might have some deleterious effects on the liver function.
Abo, K. A., A.A. Fred-Jaiyesimi,and A.E.A. Jaiyessimi (2008). Ethnobotanical studies of medicinal plants used in the management of diabetes mellitus in South Western Nigeria. Journal of Ethnopharmacology, 115: 67- 71.
Adjanohoun, E., V. Adjakidje, M.R.A. Ahyi, L. Ake Assi, A. Akoegninou, J. d'Almeida, F. Apovo, K. Boukef, M. Chadare, G. Gusset, K. Dramane, J. Eyme, J. - N. Gassita, N. Gbaguidi, E. Goudote, S. Guinko, P. Houngnon, Issa Lo, A. Keita, H. V. and Kiniffo, D. K (1989). Contribution aux Ã©tudes ethnobotaniques et floristiques en RÃ©publique populaire du BÃ©nin. Agence de coopÃ©ration culturelle et technique, (A.C.C.T.), Paris, 895.
Bodansky,M and Bodansky,O.J.(1932).J.Biol.Chem.99,197.
Burtis CA, Ashwood ER and Bruns DE (2006), Tietz Textbook of Clinical Chemistry and Molecular Diagnostics.eds. 4th ed. St. Louis, Missouri: Elsevier Saunders, Pp 543-546.
Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC Pp 270-271.
Desouter, S. (1991). PharmacopÃ©e humaine et vÃ©tÃ©rinaire du Rwanda.MusÃ©e royal de l'Afrique centrale Tervuren. Ann. Sc. Eco., 22: 254.
Desta, B. (1994). Ethiopian traditional herbal drugs.Part III: Anti-fertility activity of 70 medicinal plants. Journal of Ethnopharmacology, 44: 199 â€“ 209.
Giannini, E. G., Testa, R. and Savanrino, V. (2005). Liver enzyme alteration: a guide for clinicians. CMAJ 172 (3): 367-79.
Giboney, P. (2005 )Mildly Elevated Liver Transaminases in the Asymptomatic Patient. Am Fam Physician; 71:1105â€“10.
Goldbatt P. and Manning J. (1998). Gladiolus in Southern Africa. Fernwood Press, Vlaeberg, Cape Town, 12(4) Pp 76 - 79.
Goldblatt P. (1993). Iridaceae. Flora Zambesiaca 12(4). (Fernwood Press, Cape Town), Pp. 138â€“42.
Hyde, M.A., Wursten, B.T. & Ballings, P. (2012). Flora of Zimbabwe: Species information: Gladiolus unguiculatus, Pp. 41â€“42.
Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL and Jameson JL eds, (2005) Harrison's Principles of Internal Medicine, 16th Edition, McGraw Hill, Pp 1811-1815.
McPherson K, Marsh T, Brown M (2007) Tackling obesities: future choicesâ€”modelling future trends in obesity and their impact on health. Report for Foresight. Government Office of the Chief Scientist.
Nyblom, H., Bjornsson, E., Simren, M., Aldenborg, F., Almer, S and Olsson, R. (2006). â€œThe AST/ALT ratio as an indicator of cirrhosis in patients with PBCâ€. Liver Int. 26 (7): 840-5.
Pagana K, Pagana T. (2006) Mosby's Manual of Diagnostic and Laboratory Tests. 3rd Edition, St. Louis: Mosby Elsevier, Pp 49-51.
Reitman, S and Frankel, S.(1957). Method of Alanine and Aspartate aminotransferase determination.Am.J.Clin. Pp 28-56.
Tadesse, D. (1994). Traditional use of some medicinal plants in Ethiopia. 1: 273-293, Proceedings of the 13th plenary meeting of AETFAT, Zomba, Malawi, 1 (2):1514.
Wiechselbaum, T.E. (1946).Quantitative determination of total protein in serum or plasma Am. J. Clin. Pathol., 16:40-49.
Zimmermann, M. (1983). Ethical Guidelines for Investigations of Experimental Pain in Conscious Animals, Pain 16(2): 109-110.
Copyright (c) 2013 Mintage Journal of Pharmaceutical and Medical Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.