HISTOPATHOLOGICAL STUDIES OF LIVER FUNCTION IN RATS FED ON GINGER LILLY CORM MEAL

  • Yusuf S Omeh Department of Biochemistry, Michael Okpara, University of Agriculture, Umudike, Abia State, Nigeria
  • Omokwe K Department of Biochemistry, Michael Okpara, University of Agriculture, Umudike, Abia State, Nigeria
  • P.C Ugwu Okechukwu Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria
  • O C Enechi Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria

Abstract

The effect of feeding Gladiolus unguiculata corm on a few liver function markers were evaluated in this study using albino Wistar rats. Twenty rats were randomly divided into four groups of five rats each. Various concentration of G. unguiculata formulations were fed to the test groups excluding the negative control which received normal feed for the 28 days of analysis. At the end of the feeding period the levels of the serum liver function markers of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP) and Protein were determined. Mean serum liver function markers were all increased when compared with the control with only AST liver marker deviating. The ALT activity increased from 36.0 + 3.16 in the control to 38.0 + 3.16 in 20%. The AST significantly increased (p<0.05) from 66.0 + 3.16 in the 20% to 88.0 + 3.16 in the control group. ALP significantly increased from 47.0 +3.16 in the control group to 56.0 + 3.16 in 20%. Protein also increased from 7.0 +0.316 in the control group to 7.8 +0.316 in 20%. The results emanating from this study suggest that Gladiolus unguiculata corm formulations might have some deleterious effects on the liver function.

Author Biographies

Yusuf S Omeh, Department of Biochemistry, Michael Okpara, University of Agriculture, Umudike, Abia State, Nigeria
Department of Biochemistry, Michael Okpara, University of Agriculture, Umudike, Abia State, Nigeria
Omokwe K, Department of Biochemistry, Michael Okpara, University of Agriculture, Umudike, Abia State, Nigeria
Department of Biochemistry, Michael Okpara, University of Agriculture, Umudike, Abia State, Nigeria
P.C Ugwu Okechukwu, Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria
O C Enechi, Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria

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Published
2013-04-01
How to Cite
Omeh, Y. S., K, O., Okechukwu, P. U., & Enechi, O. C. (2013). HISTOPATHOLOGICAL STUDIES OF LIVER FUNCTION IN RATS FED ON GINGER LILLY CORM MEAL. Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315), 55-58. Retrieved from http://mjpms.in/index.php/mjpms/article/view/121