EFFECT OF MODE OF ADDITION OF SUPERDISINTEGRANTS ON FAST DISSOLVING TABLET OF DICLOFENAC SODIUM

Anmol Eldose, Nidhi Patel, Smit Choudhary, Hitesh Jain, Umesh Upadhyay

Abstract


Objective: The aim of this present work is to formulate and evaluate fast disintegrating tablets studying the mode of incorporation of superdisintegrants such as sodium starch glycolate, croscarmellose sodium, crosspovidone, on dissolution profile and disintegration time of Diclofenac Sodium a poorly water soluble drug was studied. Methods: The fast dissolving diclofenac tablets were prepared using wet granulation method. The superdisintegrants were incorporated by extragranularly, intragranularly and intra-extragranularly in wet granulation method. Result and Conclusion: The results indicated that crosspovidone, when incorporated intra-extragranularly in wet granulation method significantly enhanced the release profile of diclofenac sodium. Crosspovidone was the most effective superdisintegrant in decreasing disintegration time of different tablet formulations (1.22 minutes when intra-extragranularly incorporated).the formulation F5 containing crosspovidone as an intra and extra-granular addition shows the 90.37% drug release within 60 mins.


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