A PRELIMINARY STUDY ON THE ANTIPROLIFERATIVE AND CYTOSTATIC EFFECT OF NIGERIAN HONEY
AbstractBackground: Cancer is a significant health problem and also a major cause of death in both developing and developed countries all over the world. The World Health Organization (WHO) has ranked it among the leading causes of death, as about 7.4 million (13%) deaths in 2004 were as a result of cancer. Chemoprevention simply refers to the use of pharmacological or dietary agents to prevent induction, inhibit or even delay the advancement of cancer. These agents should have antiproliferative or even cytostatic effect to achieve this aim. There have been recent claims of various naturally occurring products having anticancer effect, with honey being one of these products Aim: The aim of this study is to evaluate if Nigerian honey has antiproliferative and cytostatic potentials. Materials and Method: Honey solutions A-E were prepared from pure honey. The study was carried-out on rapidly proliferating seeds (Sorghum bicolor) and the mean radicle lengths (mm) were taken after 24, 48 and 72 hours. Results: The seeds treated with methotrexate showed a remarkable retarded radicle growth compared to control. While those treated with honey solutions A-C showed a high degree of inhibition of proliferation of the seeds radicle. Their effects were significant (P<0.05) at 48 and 72 hours. Honey solutions D and E showed a total cytostatic effect on the seeds throughout the study. Conclusion: The study reveals that Nigerian honey has a potential for causing antiproliferative and cytostatic effects on rapidly proliferating cells
World Health Organization. NMH Fact sheet 2010. [Available at www.who.int/cancer].
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57-70.
Saravana KJ and Mahitosh M. Antiproliferative Effects of Honey and of Its Polyphenols: A Review. J Biomed Biotechnol, 2009;13.
Rumza A. Rashid and Azimathol H.L PIHIE. The Antiproliferative Effects of Zingiber zerubet extracts and fractions on the Growth of Human Breast Carcinoma Cell Lines. Malas J Pharmaceut Sci, 2005;3(1):45-52.
Stefan B. Honey in Medicine. Bee Product Science, 2012. [Available at www.bee-hexagon.net].
John AOO, Olasunkanmi OO, Tinuade AO, and Oyeku AO. Comparison of Healing of Incised Abscess Wounds with Honey and EUSOL Dressing. J Altern Complement Med, 2005;(11)3:511-513.
Ayinde BA, Omogbai EKI and Ikpefan EO. Comparative Cytotoxic and Antiproliferative Effects Of Persea americana mill (Lauraceae) Leaf, Stem And Root Barks. Niger J Pharmaceut Sci, 2011;(10):189-823.
Wicaksono BD, Handoko YA, Arung ET, Kusuma IW, Yulia D, Pancaputra AN, et al. Antiproliferative effect of the methanol extract of piper crocatum ruiz and pav leaves on human breast (T47D) cells in vitro. Trop J Pharm Res 2009;8:345-52.
Cragg GM, Newman D.J. Plants as a source of anticanceragents. J Ethnopharmacol, 2005; 100:72-79.
Tan G, Gyllenhaal C and Sorjarto DD. Biodiversity as asource of anticancer drugs. Curr Drug Targets, 2006; 7: 265-277.
McLaughlin JL, Chang C and Smith DI. Bench-top bioassays for the discovery of bioactive natural products: an update. In: Atta-ur- Rahman, editor. Studies in Natural Products Chemistry. Amsterdam: Elsevier Science Publishers B.V, 1991; 9:383-409.
Obuotor EM and Onajobi FD. Preliminary evaluation of cytotoxic properties of Raphia hookeri fruit mesocarp. Fitoterapia, 2000; 71:190-2.
Shogbaike DA, Ogundaini AO and Adesanya SA. The effects of some synthesized stilbene analogues on Artemia salina naupalii and germination of Sorghum bicolor seeds. Niger J Nat Prod Med, 2002;6:19-25.
Chinedu E, Arome D, Ameh F S and Ilomuanya U. Assessment of the Antiproliferative Potential of Citrullus lanatus (Water Melon) Fruit Juice. Mintage J Pharmaceut Med Sci 2014; 3(2):1-3.
Eleazu CO, Oti E, Eleazu KC and Obi V. Nutrient composition, polyphenolic contents and free radical scavenging activities of five honey samples from NRCRI, Umudike and different locations in South Eastern Nigeria. Afri J Food Sci Tech, 2012 ;(3):7160-167.
Izquierdo L, Sendra JM. Citrus fruits: Composition and characterization. In: Caballero B, Trugo L, Finglas P, editors. Encyclopedia of Food Sciences and Nutrition. Vol 2. Oxford, UK: Academic Press; 2003.
Wollgast J and Anklam E. Review on polyphenols in Theobroma cacao: Changes in composition during the manufacture of chocolate and methodology for identification and quantification. Food Res Int, 2000;6:423-47.
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