• Giani Maria Cavalcante Institute of Technology of Pernambuco http://orcid.org/0000-0002-0143-3364
  • Amanda Evanile da Silva Cabral University Center Mauricio de Nassau
  • Camila Cassia Silva University Center Mauricio de Nassau


Introduction: The Flavonoids are derivatives constituted of phenolic and are classified according to substitutions of pyran rings, are present in plants and your biological, pharmacological and medicinal properties were broadly registered. Objective: the aim of study was realized a mini review about leishmanicidal activity of flavonoids isolated of vegetable and synthesized. Methods: the review was conducted used four databases which included SciFinder®, MEDLINE-PubMed, Web of Science and LILACS, used different combinations of the keywords. Results: A total of 1.366 abstracts were identified in databases and according the inclusion and exclusion criteria 24 papers were selected to systematic review and your analysis showed that the leishmanicidal activity was performed with 41 isolated flavonoids of vegetal resource and 23 synthesized flavonoids. 

Author Biographies

Giani Maria Cavalcante, Institute of Technology of Pernambuco
Laboratory of Biotechnology - Institute of Technology of Pernambuco.
Amanda Evanile da Silva Cabral, University Center Mauricio de Nassau
Camila Cassia Silva, University Center Mauricio de Nassau


Kumar S, Pandey A. Chemistry and Biological activities of flavonoids: An overview. The Scientific World Journal, 2013; 23:1-16.

Preeti K, Sarma RA and Mala A. Isolation and identification of flavonoids from Prosopis Juliflora. Mint Jour of Pharma and Medical Scien 2017;1:1-3..

Thongnest S, Kool LT, Wetprasit N, Sutthivaiyakit P, Sutthivaiyakit S. Eriosema chinense: A rich source of antimicrobial and antioxidant flavonoids. Phytochemistry, 2013; 98: 353-359.

Citoglu GS, Sever B, Antus S, Baitz-Gacs F, Altanlar N. Antifungal activity flavonoids from Ballota glandulosissima. Pharmaceutical Biology, 2002; 41: 483-486.

Kassim M, Achoui M, Mustafa MR, Mohd MA, Yusoff KM. Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflamattory activity. Nutrition Research, 2010; 30: 650-659.

Kandhare AD, Alam J, Mithun VK, Patil AS, Bodnankar L. Wound healing potential of naringin ointment formulation via regulating the expression of inflammatory, apoptotic and growth mediators in experimental rats. Pharmaceutical Biology, 2015; 54: 419-432.

Perez-Vizcaino F, Duarte J, Jimenez R.; SANTOS-BUELGA, C.; OSUNA, A. Antihyertensive effects of the flavonoid quercetin. Pharmacology Reports, 2009; 61: 67-75.

Lu J, Papp LV, Jianguo F. Inhibition of mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer Research, 2006; 66: 4410-4418.

Silva-Filho AA, Resende DO, Fukui MJ, Santos FF, Pauletti PM, Cunha WR, Silva MLA, Gregorio LE, Bastos JK, Nanayakkara NPD. In vitro antileihmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae). Fitoterapia, 2009; 80: 478-482.

Harvey AL, Edraba-Ebel R, Quinn RJ. Re-emergenge of natural products for drugs discovery in the genomics era. Nature Reviews Drug Discovery,2015; 14: 111-129.

WORLD HEALTH ORGANIZATION (WHO) Control of leishmaniasis: report of a meeting of the WHO Expert Committee on the Control of Leishmaniasis. World Health Organization, Geneva, 2010.

Copeland NK, Aronson NE. Leishmaniasis: treatment updates and clinical practice guidelines review. Current opinion in Infectious Diseases, 2015; 28: 426-437.

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JPA, Clarke M, Devareaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analysis of studies that evaluate health care interventions: explanation and elaboration. BMJ, 2009; 339: 7-18.

Barreto SSR, Albuquerque-Junior RRLC, Araújo AS, Almeida JRGS, Santos MRV, Barreto AS, Santana JM, Siqueira-Lima PS, Quintans JSS, Quintans-Junior LJA systematic review of the wound-healing effects of monoterpenes and iridoid derivatives, 2014;19: 846-862.

Cruz EM, Silva ER, Maquiavel CC, Alves ESS, Lucon-Junior JF, Reis MBG, Toledo CEM, Cruz FG, Vannier-Santos MA. Leishmanicidal activity of Cecropia pachystachya flavonoids: arginase inhibition and alterred mitocondrial DNA arragement. Phytochemistry, 2013; 81: 71-82.

Cabanilhas BJ, Lamer AC, Olagnier O, Castillo D, Arevalo J, Valadean C, Costa A.; Pippy B, Bourdy G, Savvain M, Fabre N. Leishmanicidal compounds and potent PDRY activators from Renealmia thyrsoidea (Ruiz e Pau) Poepp e Endl. Journal of Enthomopharmacology, 2014; 197:149-155.

Ramirez-Garcia I, Marín C, Rosales MJ, Sanches RG, Moreno MS. Leishmanicidal activity of nine novel flavonoids from Delphinium staphisagria. The scientific world Journal, 2012; 102: 1-10.

Rizk YS, Fischer A, Cunha MC, Rodrigues PO, Marques MCS, Matos MFC, Kadai MCT, Carallo CA, Arruda CCP. In vitro activity of the hydroethanolic extract and biflavonoids isolated from Selaginella sellowii and Leishmania amazonensis. Memorias do Instituto Owaldo Cruz, 2014; 109: 1050-1065.

Salen MM, Capers J, Rijos S, Werbovetz KA. Antiparasitic activity C-genenyl flavonoids from Mimulus bigelovii. Phytoterapy Research, 2011; 25: 1246-1244.

Attiova B, Lagnika L, Yeo OD, Antheaume C, Kaise M, Weniger B, Lobstein NA, Vonthron-Seecheav VC. In vitro antiplasmodial and antileishmanial activites of flavonoids from Anogeissus leiocarpus (Combretaceae). International Journal Pharmaceutical Sciences Review and Research, 2011; 11: 1-6.

Rudrapaul P, Sarma IS, Das N, De VC, Bhattacharjje S, Dinda AB. New flavonol methylether from the leaves of Vitex pedunculatis exhibits potential inhibitory activity against Leishmania activation of NO. European Journal of Medicinal Chemistry, 2014; 87: 328-335.

Lage PS, Andrade PHR, Lopes AS, Fumagali MAC, Valadares SG, Duarte MC, Lage DP, Costa LE, Martins VT, Ribeira TG, Souza-Filho TD, Tavares CAP, Padua RM, Leite JPV, Coelho EA. F. Strychnos pseudoquina and its purified compounds presente na effective in vitro antileishmanial activity. Evidence-Based Complementary and Alternative Medicine, 2013; 11: 1-9.

Grecco SS, Reimão JQ, Tempeno AG, Sartorelli P, Cunha RLO, Romoff P, Ferreira MJP, Favero DA, Lago JH. In vitro antileishmanial and antitryoanossomal activies of flavonones from Baccharis retusa D.C (Asteraceae). Experimental Parasitology, 2012; 130: 141-145.

Cota BB, Siqueira EP, Oliveira DM, Alves TMA, Sobral MEG, Rabelo A, Zani CL. Chemical constituints and leishmanicidal activity from leaves of Kielmeyera variabilis. Brazilian Journal of Pharmacology, 2012; 22: 1253-1258.

Akimanya A, Midino JO, Matassyoh J, Okanga F, Masila VM, Walker L, Tekwani BL, Muhammad I, Omasa LK. Two polymethoylated flavonoids with antioxidant activies and leishmanicidal from the leaf exudates of Microglossa pyrifloria. Phytochemistry Letters, 2015; 11: 183-187.

Mai LH, Chabot GG, Grellier P, Quetin L, Domontes V, Poulain LS, Espindola S, Michel HTB, Vo B, Deguin R. Antivascular and antiparasitic of natural and hemyssintetic flavonoids from new caedonian Gardenia species (Rubiaeae). European Journal of Medicinal Chemistry, 2015; 93: 93-100.

Beer MF, Frank FM, Elso DG, Bivona AE, Cerny N, Gibertig G, Macchiodi EL, Martino VS, Alonso MR, Sulsen VP, Carzola SI. Trypanocidal and Leishmanicidal activities of flavonoids isolated from Stevia Satureiifolia var Satureiifolia. Pharmaceutical Biology, 2017; 54: 2188-2195.

Clavain M, Carzola S, Spina R, Sosa MA, Malchiodi E, Martino V, Muschietti L. Antiprotozoal activity of flavonoids from Eutatorium arnottianum. Journal od Parasitic Diseases: Diagnosis and Therapy¸ 2016; 2: 1-6.

Maldonado EM, Salamanca E, Gimenez A, Sterner D. Antileishmanial metabolites from Lantana Balansae. Brazilian Journal of Pharmacology, 2016; 25: 180-183.

Iqbal K, Iqbal J, Kongstad KT. The characterization of antileishmanial compounds from Lawsonia inermis leaves using semi-flight resolution antileishmanial profiling combined with HPLC-HRMS-SPE-NMR. Frontiers in Parasitology, 2016; 8: 1-7.

Nazarian Z, Emani S, Heydari S, Ardestani SK, Nakhjiri M, Poorajab F, Shafiee EA, Foroumadi. A. Novel antileishmanial chalconoids: synthesis and biological activity of 1-on-3-(6-Chloro-2H-Chromen-3-yl) propren-1-ones. European Journal of Medicinal Chemistry, 2010; 45: 1424-1430.

Wong ILK, Cha KI, Chow LMC. Flavonoids dimers as novel potent antileishmanial agents. Journal Medicinal Chemistry, 2012; 55: 8891-8902.

Wong ILK, Chan KF, Chen YF, Lun ZR, Chan TH, Chow LMC. In vitro and In vivo efficacy of novel flavonoid dimers against cutaneous leishmaniasis. Antimicrobial Agents Chremotherapy, 2014; 13: 3379-3388.

Lewin G, Grupta S, Verma A, Puri SK, Loisean PM. In vitro antileishmanial properties of new flavonoids against Leishmania donovani. Biomedicine e Preventive Nutrition, 2011; 1:168-171.

Silva ER, Maquiaveli CC, Magalhães PP. The leishmanicidal flavonols and quercetin target Leishmania amazonensis arginase. Experimental Parasitology, 2012; 130:183-188.

Fouromadi A, Emani S, Sorkhi M, Nakhjiri M, Nazarian Z, Hetdaris P, Pourrajab BF, Shafire A. Chremeno-based synthetic chalconas and potente antileishmanial agentes: synthesis and biological activity. Chemical Biology Drug Discovery, 2010; 75: 590-596.

Buarque CD, Militão GCG, Lima DJB, Costa-Lotufo LV, Pessoa C, Moraes OM, Cunha-Junior EF, Torres-Santos EC, Netto CD, Costa PR. Pterocarpanquinones, Aza-pterocaroanquinone and derivates: synthesis, antineoplasic activity on human malignant cell lines and antileishmanial activity on Leishmania amazonensis. Bioorganic Medicinal Chemistry, 2011; 19: 6881-6891.

Baldin JL, Alcantara BGV, Domingos SOS, Soares MG, Caldas IV, Novaes RD, Oliveira TB, Lago JHG. The correlation between chemical structures and antioxidant, prooxidant and antitrypanossomatid proprieties of flavonoids. Oxidative Medicine and Celullar Longevity, 2017; 2017: 1-28.

Wink M. Medicinal Plants: A source of anti-parasitic secondary metabolites. Molecules, 2012; 17: 12771-12791.

Alvar J, Croft S, Ollario P. Chemotherapy in the treatment and control of leishmaniasis. Advances in Parasitology, 2006; 61: p.223-274.

Singh N, Mishra BB, Bajpai S, Singh RK, Tiwari VK. Natural product based leads to fight against leishmaniasis. Bioorganic & Medicinal Chemistry, 2014; 22: 18-45.

Mittra B, Saha A, Chowdhury AR, Pal C, Mandal S, Mukhopadhyay S, Bandyopadhyay S, Majumder HK. Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediate kinetoplast DNA cleavage leading to apoptosis. Molecular Medicinal, 2000; 6: 527-541.

Da Silva SA, Costa SS, Mendonça SC, Silva EM, Moraes VL, Rossi-Bergmann B. Therapeutic effect of oral Kalanchoe pinnata leaf extract in murine leishmanisis. Acta Tropica, 1995; 60: 201-210.

Tiuman TS, Santos AO, Ueda-Nakamura T, Dias-Filho BP, Nakamura CV. Recent advances in leishmaniasis treatment. International Journal of Infectious Diseases, 2011; 15: 525-532.

Nagle AS, Khare S, Kumar AB, Supek F, Buchynskyy A, Mathison CJN, Chennamaneni K, Pendem N, Buckner, FS, Gelb MH, Molteni, V. Recent developments in Drug Discovery for leishmaniasis and human African Trypanosomiasis. Chemical Reviews, 2012; 114: 11306-11347.

Patil RS, Patil MS, Kshirsagar SS, Chaudhari PS, Bayas JP, Oswal RJ. Synthetic and natural products against Leishmaniasis: A review. Word Journal Public Health Sciences, 2012; 1: 1-7.

Tasdermir D, Kaiser M, Brun R, Yardley V, Schimidt TJ, Tosun F, Ruedi P. Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: In vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. Antimicrobial Agents and Chemotherapy, 2006; 50: 1352-1364.

How to Cite
Cavalcante, G. M., Cabral, A. E. da S., & Silva, C. C. (2018). LEISHMANICIDAL ACTIVITY OF FLAVONOIDS NATURAL AND SYNTHETIC: A MINIREVIEW. Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315), 25-34. Retrieved from http://mjpms.in/index.php/mjpms/article/view/317