FORMULATION AND EVALUATION OF DICLOFENAC GEL

Chinmaya Keshari Sahoo, Muvvala Sudhakar, D. Venkata Ramana, K. Satyanarayana

Abstract


Objective: The objective of the study was to develop a topical gel of diclofenac sodium (DS) 1%. Methods: Hydrophilic polymers like Carbopol 940 of varying concentrations were used in an attempt to develop topical hydrogel formulations of diclofenac sodium. Agitation followed by neutralization with neutralizing agent was done to get gel. Evaluation tests for visual appearance, pH, viscosity, spreadability, drug content, ex vivo drug release were carried out. Results: From the study it was concluded that F3 batch of gel containing diclofenac showed good homogeneity, spreadability, pH value and rheological properties within the limits allowed for dermatological preparations. No prominent changes in physicochemical properties of formulation were observed after exposure to accelerated conditions of temperature (40 ± 2oC) and humidity conditions (75 ± 5%RH).Conclusion: It was observed that dissolution profile of diclofenac is more in F3 batch and showed good characteristics for drug delivery. 


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References


Enkelejda Goci, Entela Haloci, Skerdilaid Xhulaj, Ledjan Malaj. Formulation and in vitro evaluation of diclofenac sodium gel. International Journal of Pharmacy and Pharmaceutical Sciences, Int J Pharm Pharm Sci,2014; Vol 6, Issue 6, 259-261.

Sanna V, Peana AT, Moretti MDL. Development of new topical formulations of diphenhydramine hydrochloride: in vitro diffusion and in vivo preliminary studies. International Journal of PharmTech Research 2010;2(1):863-9.

Monica AS and Gautami J: Design and Evaluation of Topical Hydrogel Formulation of Diclofenac Sodium for Improved Therapy.Int J Pharm Sci Res 2014; 5(5): 1973-80.

Sahoo CK, Nayak PK, Sahoo TK, Dasari P, Dandamundi S. A Review of Transdermal drug delivery system. Journal der Pharmazie Forschung. 2013;2(1):32-56.

Singh MP, Nagori BP, Shaw NR, Tiwari M , Jhanwar B. Formulation Development &Evaluation of Topical Gel Formulations Using Different Gelling Agents and Its Comparison with Marketed Gel Formulation. International Journal of Pharmaceutical Erudition. 2013, 3(3), 1-10

Ahuja N, Saini V, Rasayan J. Formulation and evaluation of diclofenac sodium gel by using natural polymer. Chem Vol No3 2008;1:564-6.

Stozkowska W. Effect of various vehicles on diclofenac sodium and indomethacin pharmaceutical availability. Acta poloniae pharmaceutica 2002;59(4):253-8.

Kaur J, Srinivasan KK, Joseph A, Gupta A, Singh Y, Srinivas KS, et al. Development and validation of stability indicating method for the quantitative determination of venlafaxine hydrochloride in extended release formulation using high performance liquid chromatography. Journal of pharmacy & bioallied sciences 2010;2(1):22-6.

Bucur L, Istudor V. Hîrjău V, Elaeagnus angustifolia L. Flower soft extract valorification in a dermatological preparation note 2 Dermatological preparation rheologic control Farmacia

;57(3):309-14.

Sahoo CK, Satyanarayana K, Bomma NG, Modugu KR, Nayak PK, Sarangi DK,Sahoo TK. Formulation and evaluation of bifonazole organogel for the application of topical drug delivery system. Der Pharmacia Sinica, 2013; 4(3):67-74.

Turk J. Hasçicek C, Bediz-Ölçer A, Gönül N. Preparation and evaluation of different gel formulations for transdermal delivery of meloxicam Pharm Sci 2009;6(3):177-86.

Aejaz A, Azmail K, Sanaullah S, Mohsin AA. Formulation and in vitro evaluation of aceclofenac solid dispersion incorporated gels. International Journal of Applied Pharmaceutics 2010;2(1):7-12.

Nayak P, Kumar R. Retromastoid-sub occipital: A novel approach to cerebello pontine angle in acoustic neuroma surgery-our experience in 21 cases. Journal of neurosciences in rural practice 2011;2(1):23-6.


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