Abbas Yazdanpanah, Masoud Karimi, Hassan Ghiyasi



Medicines are the most important and common method of diseases treatment all over the world and they designate a great part of health costs. Using treatment standard guidelines is one of the most important strategies of rationalizing medicines consumption. This study investigates the impact of using clinical standard guidelines on the consumption rate of Pantoprazole.


In this study, which was conducted by the method of designing interrupted time-series in Shiraz ShahidFaghihi Hospital, the rate of consuming medicine from one year before impartment of clinical standard guideline to three month after its implementation ( total 48 months) was registered monthly. Changes of medicine consumption rate were analyzed using repeated measure ANOVA and Bonferroni post hoc test using SPSS 21 software and in significance level of 0.05.


The rate of consumption of Pantoprazole during four years study (the year before guideline implementation and three years after guideline implementation) showed a significant reduction (F=44.91, df=1.59, Pval<0.001). This reduction occured in the first year of implementing the guideline comparing the previous year (Pval< 0.001) and the rate of medicine consumption didn’t show a significant change during the next years.


In sum, it seems that implementing the clinical standard guideline has been able to significantly reduce the consumption rate of Pantoprazole in the hospital. Though, it is suggested that broader studies in longer time periods is performed in this field by comparing various hospitals.

Keywords: intradermal pantoprazole, clinical standard guideline, hospital

Full Text:



- Picon-Camacho, S.M., et al., An assessment of the use of drug and non-drug interventions in the treatment of Ichthyophthirius multifiliis Fouquet, 1876, a protozoan parasite of freshwater fish. Parasitology, 2012. 139(2): p. 149-190.

- STANDARD TREATMENT GUIDELINES. 2016, Department of Public Health & Family Welfare Madhya Pradesh.

- Antonakis, N., et al., Seeking prescribing patterns in rural Crete: a pharmacoepidemiological study from a primary care area. Rural and Remote Health, 2006. 6(488).

A, 4- M., Health in the Islamic Republic of Iran. Medical Education 1997. 30: p. 370-75

- Ratanawijitrasin, S. and E. Wondemagegnehu, Effective drug regulation: a multicountry study. 2002: World Health Organization.

Organization, W.H., Promoting rationaluse of medicines: core components. 2002.6-

- Ambwani S, M.A., Rational Drug Use. . Health Administrator, 1987. 19(1): p. 5-7

. 8- Laing, R., Rational drug use: an unsolved problem. Tropical doctor, 1990. 20(3): p. 101-103.

Theodorou, M., et al., Factors9- influencing prescribing behaviour of physicians in Greece and Cyprus: results from a questionnaire based survey. BMC health services research, 2009. 9(1): p. 150.

- Iranian Ministry of Health and Medical Education.

- Developing, Implementing, and Monitoring the Use of Standard Treatment Guidelines: a SIAPS How-to Manual. 2015.

- Moradi, M., S. Raeesi, and Z. Sepehri, Audit of IV pantoprazole: pattern of administration and compliance with guideline in a teaching hospital. SpringerPlus, 2016. 5(1): p. 1749.

- Mahmoudi, L., et al., Implementation of pharmaceutical practice guidelines by a project model based: clinical and economic impact. Medicine, 2015. 94(42).

.14- Zolfagharian, F., et al., Drug utilization evaluation of albumin in a teaching hospital of Mashhad, Iran: an interventional pre–post design study. International journal of clinical pharmacy, 2017. 39(4): p. 704-711.

- Buckley, M.S., S.L. Kane-Gill, and S.A. Patel, Clinical and economic evaluation of an evidence-based institutional epoetin-utilization management program. Clinical therapeutics, 2013. 35(3): p. 294-302.

- Van Vliet, E., et al., The effects of guideline implementation for proton pump inhibitor prescription on two pulmonary medicine wards. Alimentary pharmacology & therapeutics, 2009. 29(2): p. 213-221.


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.