ANTIMICROBIAL ACTIVITY OF SIDEROXYLON OBTUSIFOLIUM: IN VITRO ASSAYS IN PERSPECTIVE IN THE TREATMENT OF CHRONIC WOUNDS.

Giani Maria Cavalcante, Amanda Soares da Silva, Camila Cassia Silva, Amanda Evanile da Silva Cabral

Abstract


 The aim of this study was investigating the antimicrobial activity of crude extract and organic fractions of Sideroxylon obtusifolium against bacteria associated by chronic wounds. The tests were conducted with crude extracts of leaves and the organic fraction of hexane, ethyl acetate and methanol against strains Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12228), Escherichia coli (ATCC 25922), Pseudomona aeruginosa (ATCC 27853) and Proteus mirabilis (ATCC 7002) through in agar-well diffusion assay and determination of Minimal Inhibitory Concentrations (MIC). The results showed that crude extract of leaves (CEL) and the organic fraction methanol (MeOH) of S. obtusifolium were the most active with the diameter of inhibition zones statistically significant to all tested microorganisms, when compared with standard drug, beside   that the best results of CIM. Chemical study to analyzed specie to extraction, isolation and characterization of compounds is recommended to investigate the antimicrobial activity.

 


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