ROLE OF CALCIUM IONS IN AQUEOUS HUMOR DYNAMICS AND POTENTIAL OF CALCIUM CHANNEL BLOCKERS AS OCULAR DRUG DELIVERY AGENTS IN THE MANAGEMENT OF GLAUCOMA
Glaucoma, a progressive optic neuropathy, is the leading cause of irreversible blindness worldwide. Pharmacologic treatment forÂ glaucomaÂ is directed towards lowering intraocular pressure (IOP) to slow disease progression and delay visual field loss. Various classes of anti-glaucoma agents have been developed to lower IOP but are still being administered as topical drops. Efforts are underway to increase patient compliance and greater therapeutic benefits with the development of sustained delivery technologies. The effect of calcium channel blockers on intraocular pressure and aqueous humor dynamics remains still controversial, although preliminary evidence suggests that these drugs may be beneficial in the management of ocular hypertension and low-tension glaucoma. There is evidence of the role of calcium ions in the physiology of aqueous humor. This study aims to systematicallyÂ reviewÂ and summarize the role of calcium ions in the secretion and dynamics of aqueous humour and the potential use of CCBâ€™s as new pharmacologic options for the treatment of glaucoma.
Keywords: Glaucoma, Aqueous humor dynamics, IOP, Calcium Channel Blockers.
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