EVALUATION OF HEMATOLOGICAL PARAMETERS IN MALE PATIENTS WITH ACUTE CORONARY SYNDROME
Back ground: Acute Coronary Syndrome(ACS) refers to a spectrum of clinical presentations ranging from those for ST-segment elevation myocardial infarction (STEMI) to presentations found in non–ST-segment elevation myocardial infarction (NSTEMI) or in unstable angina(UA).
Objective: The study carried to evaluate the levels of hematological parameters in patients with ACS and healthy persons.
Patients and Methods: A total of (58) male patients with diagnosis of acute coronary syndrome were included in this study with age range (23-75year) and divided into: ST-segment elevation myocardial infarction group, non ST-segment elevation myocardial infarction group and unstable angina group as well as (30) healthy persons with age range (27-70year). Hematological parameters [hemoglobin(Hb), white blood cell(WBC), Platelets were measured for ACS patients and control by autohematology analyzer (Mindary cell count) as well as Erythrocyte Sedimentation Rate ( ESR),and Cardiac troponin I(cTn I).
Results: There were significant differences in: STEMI, N-STEMI, UA, patients regarding Hb, WBC, ESR in comparison with control, but there were non-significant differences between ACS subgroups and control regarding platelets.
Newby DE , Grubb NR and Bradbury A. Atherosclerosis in Cardiovascular disease In: Davidson's Principles and Practice of Medicine,22th Elsevier Health Sciences; Edition Walker BR, Colledge NR, Ralston SH, and Penman ID .2014;18(2): 486-590 .
Smith JN, Negrelli JM, Manek MB, Hawes EM, Viera AJ. Diagnosis and management of acute coronary syndrome: an evidence-based update. The Journal of the American Board of Family Medicine. 2015 Mar 1;28(2):283-93.
Bhuiya FA, Pitts SR, McCaig LF. Emergency department visits for chest pain and abdominal pain: United States, 1999-2008. National Center for Health Statistics (NCHS) data brief. 2010 Sep(43):1-8.
Antman EM” ST-Segment Elevation Myocardial Infarction: Pathology, Pathophysiology, and Clinical Features”In: Braunwald's Heart Disease E-Book: A Textbook of Cardiovascular Medicine Bonow RO, Mann DL, Zipes DP , 2011 chapter 54:1103-1106.
Salehi N, Eskandarian R, Sanati HR, Firouzi A, Shakerian F, Abdi S, Bakhshandeh H, Abadi MN, Nouri N, Vakili-Zarch A. White blood cell count and mortality in acute myocardial infarction. World Journal of Cardiovascular Diseases. 2013 Oct 9;3(07):458-463.
Sabatine MS, Morrow DA, Giugliano RP, Burton PB, Murphy SA, McCabe CH, Gibson CM, Braunwald E. Association of hemoglobin levels with clinical outcomes in acute coronary syndromes. Circulation. 2005 Apr 26;111(16):2042-9.
Thygesen K, Alpert JS, White HD. Universal definition of myocardial infarction. Journal of the American College of Cardiology. 2007 Nov 27;50(22):2173-95.
Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD. Third universal definition of myocardial infarction. Circulation. 2012 Oct 16;126(16):2020-35.
Jaffe AS, Babuin L, Apple FS. Biomarkers in acute cardiac disease: The present and the future. J Am CollCardiol. 2006; 48: 1.
Redfearn DP, Ratib K, Marshall HJ, Griffith MJ. Supraventricular tachycardia promotes release of troponin I in patients with normal coronary arteries. International journal of cardiology. 2005 Jul 20;102(3):521-2.
Hickman PE, Potter JM, Aroney C, Koerbin G, Southcott E, Wu AH, Roberts MS. Cardiac troponin may be released by ischemia alone, without necrosis. Clinica chimica acta. 2010 Mar 2;411(5-6):318-23.
WHITE H. White HD. Pathobiology of Troponin Elevations: Do Elevations Occur With Myocardial Ischemia as Well as Necrosis? J Am Coll Cardiol 2011; 57: 2406―8. Journal of the American College of Cardiology. 2011;58(22).
Giannoni A, Giovannini S, Clerico A. Measurement of circulating concentrations of cardiac troponin I and T in healthy subjects: a tool for monitoring myocardial tissue renewal?. Clinical chemistry and laboratory medicine. 2009 Oct 1;47(10):1167-77.
Preet K, Anchinmane VT, Sankhe S. Evaluation of micro-ESR method with Westergren method for determination of erythrocyte sedimentation rate. International Journal of Research in Medical Sciences. 2018 Jan 24;6(2):628-31.
Apple FS, Smith SW, Pearce LA, Ler R, Murakami MM, Benoit MO, Levy C, Dumas C, Paul JL. Use of the bioMérieux VIDAS® troponin I ultra assay for the diagnosis of myocardial infarction and detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome. Clinica Chimica Acta. 2008 Apr 1;390(1-2):72-5.
El Sayed ZH, Mahmoud HA, El Shall LY, El Sheshtawey FA, Mohamed MA. Impact of copeptin on diagnosis of acute coronary syndrome. Egyptian Journal of Medical Human Genetics. 2014;15(3):241-7.
Özalp B, Caglar FN, Karakurt H, Bıyık İ, Ertürk M, Yıldırım MR, Işıksaçan N, Baycan ÖF, Yazan S. Correlations between hematological indicators and other known markers in acute coronary syndromes. EJCM. 2017 Dec 15;5(4):67-74.
Røysland R, Kravdal G, Høiseth AD, Nygård S, Badr P, Hagve TA, Omland T, Røsjø H. Cardiac troponin T levels and exercise stress testing in patients with suspected coronary artery disease: the Akershus Cardiac Examination (ACE) 1 study. Clinical science. 2012 Jun 1;122(12):599-606.
Mueller M, Vafaie M, Biener M, Giannitsis E, Katus HA. Cardiac troponin T from diagnosis of myocardial infarction to cardiovascular risk prediction. Circulation Journal. 2013;77(7):1653-61.
Garg P, Morris P, Fazlanie AL, Vijayan S, Dancso B, Dastidar AG, Plein S, Mueller C, Haaf P. Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin. Internal and emergency medicine. 2017 Mar 1;12(2):147-55.
Cho KH, Jeong MH, Ahmed K, Hachinohe D, Choi HS, Chang SY, Kim MC, Hwang SH, Park KH, Lee MG, Ko JS. Value of early risk stratification using hemoglobin level and neutrophil-to-lymphocyte ratio in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. The American journal of cardiology. 2011 Mar 15;107(6):849-56.
Bae MH, Lee JH, Yang DH, Park HS, Cho Y, Chae SC. White blood cell, hemoglobin and platelet distribution width as short-term prognostic markers in patients with acute myocardial infarction. Journal of Korean medical science. 2014 Apr 1;29(4):519-26.
Dündar C, Oduncu V, Erkol A, Tanalp AC, Sırma D, Karagöz A, Karabay CY, Kılıçgedik A, Pala S, Tigen K, Izgi A. In-hospital prognostic value of hemoglobin levels on admission in patients with acute ST segment elevation myocardial infarction undergoing primary angioplasty. Clinical Research in Cardiology. 2012 Jan 1;101(1):37-44.
Mamas MA, Kwok CS, Kontopantelis E, Fryer AA, Buchan I, Bachmann MO, Zaman MJ, Myint PK. Relationship between anemia and mortality outcomes in a national acute coronary syndrome cohort: insights from the UK myocardial ischemia national audit project registry. Journal of the American Heart Association. 2016 Nov 19;5(11):e003348.
Sulaiman K, Prashanth P, Al-Zakwani I, Al-Mahmeed W, Al-Motarreb A, Al Suwaidi J, Amin H, Asaad N, Hersi A, Al Faleh H, Al Saif S. Impact of anemia on in-hospital, one-month and one-year mortality in patients with acute coronary syndrome from the Middle East. Clinical medicine & research. 2012 May 1;10(2):65-71.
Kunadian V, Mehran R, Lincoff AM, Feit F, Manoukian SV, Hamon M, Cox DA, Dangas GD, Stone GW. Effect of anemia on frequency of short-and long-term clinical events in acute coronary syndromes (from the Acute Catheterization and Urgent Intervention Triage Strategy Trial). The American journal of cardiology. 2014 Dec 15;114(12):1823-9.
Yazji K, Abdul F, Elangovan S, Ul Haq MZ, Ossei‐Gerning N, Morris K, Anderson R, Kinnaird T. Baseline anemia in patients undergoing percutaneous coronary intervention after an acute coronary syndrome—A paradox of high bleeding risk, high ischemic risk, and complex coronary disease. Journal of interventional cardiology. 2017 Oct;30(5):491-9.
Stucchi M, Cantoni S, Piccinelli E, Savonitto S, Morici N. Anemia and acute coronary syndrome: current perspectives. Vascular health and risk management. 2018;14:109.
Dharma S, Hapsari R, Siswanto BB, van der Laarse A, Jukema JW. Blood leukocyte count on admission predicts cardiovascular events in patients with acute non-ST elevation myocardial infarction. The International journal of angiology: official publication of the International College of Angiology, Inc. 2015 Jun;24(2):127.
Gururajan P, Gurumurthy P, Nayar P, Rao GS, Babu RS, Sarasabharati A, Cherian KM. Pregnancy associated plasma protein-A (PAPP-A) as an early marker for the diagnosis of acute coronary syndrome. Indian heart journal. 2012 Mar 1;64(2):141-5.
Goktas MU, Akyol PY, Karakaya Z, Payza U, Topal FE. Evaluation of white blood cell and neutrophil/lymphocyte ratio in acute coronary syndrome patients admitted to emergency department. Journal of Biomedical Research. 2018;29(10):2009-14.
Palmerini T, Mehran R, Dangas G, Nikolsky E, Witzenbichler B, Guagliumi G, Dudek D, Genereux P, Caixeta A, Rabbani L, Weisz G. Impact of leukocyte count on mortality and bleeding in patients with myocardial infarction undergoing primary percutaneous coronary interventions: analysis from the Harmonizing Outcome with Revascularization and Stent in Acute Myocardial Infarction trial. Circulation. 2011 Jun 21;123(24):2829-37.
Han YC, Yang TH, Kim DI, Jin HY, Chung SR, Seo JS, Jang JS, Kim DK, Kim DK, Kim KH, Seol SH. Neutrophil to lymphocyte ratio predicts long-term clinical outcomes in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Korean circulation journal. 2013 Feb 1;43(2):93-9.
Yayan J. Erythrocyte sedimentation rate as a marker for coronary heart disease. Vascular health and risk management. 2012; 8:219.
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