DEVELOPMENT AND EVALUATION OF HERBAL TOPICAL GEL FOR ITS ANTI-OXIDANT AND ANTI-BACTERIAL EFFECT
Introduction: Herbal medicine has become a thing of global importance for medicinal and economical. Herbal remedies are getting popular as they are avoiding typical side effects of allopathic medicines. Objectives: The present research has been undertaken with the aim to formulate and evaluate the herbal gels for its antioxidant and antibacterial effect. Method: The antioxidant potential was investigated by in vitro models like scavenging of DPPH radical, ABTS radical scavenging assay, lipid peroxidation assay and bleaching of pyrogallol red by peroxynitrite. Gel formulations were prepared by using Carbapol 940 as a gel base. The skin pH (6.8-7) was maintained by the dropwise addition of Tri-ethanolamine. The physical parameters of formulated gel, homogeneity, pH, viscosity and Spreadability were evaluated. The evaluation of the gels for antibacterial efficiency is done by agar diffusion method against some bacterial agents. Result: The herbal gels showed that formulations containing Punica extract and berberis extract have better antibacterial activity. Conclusion: The formulation similar to this kind of combination can be very useful and can make the herbal society to grow in a good way.
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