PHYTOSOMES : A NEWER TREND IN HERBAL DRUG DELIVERY
Phytosomes, are smaller in structures which distributed as transition between the conventional and novel drug delivery system. These are the cells, which can carry themselves from a hydrophilic to the lipid environment of the cell membrane, which eventually reaches the bloodstream. Various drug delivery systems like liposomes, niosomes, transferosomes, Ethosomes, colloidosomes etc. are developed to carry the drug to the site of action without its metabolism. The major concern with respect to phytoconstituents having different chemical nature is its bioavailability and effective dosage concentration which could be overcome by means of phytosome technology. Phytosomes are the complexes prepared by mixing polyphenolic phytoconstituents and phosphatidylcholine in molar ratio. Phytosomes are condescending to the conventional drug delivery systems in terms of pharmacokinetic and pharmacodynamic properties. Phytosomes have been refined for therapeutic uses like cardiovascular, anti-inflammatory, immunomodulator, anticancer, antidiabetic etc. The review article provides the highlights for method of preparation, properties, advantages, characterization, and applications of phytosomal formulation.
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