Keywords: .


The neglected tropical diseases are the most common conditions affecting the poorest globally in sub-Saharan Africa with billions of people infected with one or more of the neglected tropical diseases. The World Health Organization has identified 17 core neglected tropical diseases among the numerous ones which exist globally. The global burden of these diseases has prompted a lot of interventions from different international and national organizations aimed at fighting to eliminate, eradicate or control the diseases by 2020. This review identifies the risk factors of the major neglected tropical diseases and describes the epidemiology, global burden of the diseases as well as highlights on the roadmap in tackling the diseases which focuses in eliminating, eradicating and controlling them by 2020.


World Health Organization (2010). Working to overcome the global impact of neglected tropical diseases: first WHO report on neglected tropical diseases. WHO, Geneva, Switzerland. who/htm/ntd/2013.1.

Hotez, P. J., Molyneux, D. H. Fenwick, A., Kumaresan, J. & Sachs, S. E. (2007). Control of neglected tropical diseases. Engl J Med 357, 1018–1027.

Liese, B., Rosenberg, M. & Schratz, A. (2010). Programmes, partnerships, and governance for elimination and control of neglected tropical diseases. Lancet, 375, 67–76. S0140-6736(09)61749-9.

Molyneux, D. H. (2010). Neglected tropical diseases—beyond the tipping point? Lancet, 375, 34.

World Health Organization (2013). Sustaining the drive to overcome the global impact of neglected tropical diseases. WHO, Switzerland, Geneva.

Hotez, P. J. & Kamath, A. (2009) Neglected tropical diseases in sub-Saharan Africa: Review of their prevalence, distribution, and disease burden. PLoS Negl Trop Dis 3, e412.

Hotez, P. J, Asojo, O. A. & Adesina, A. M. (2012). Nigeria: Ground Zero for the high prevalence neglected tropical diseases. PLoS Negl Trop Dis., 6, e1600.

Federal Ministry of Health (2013) Nigeria master plan for neglected tropical disease (NTDs) 2013–2017. Federal Ministry of Health, Abuja.

Fe‘vre, E. M., Wissmann, B. V., Welburn, S. C. & Lutumba, P. (2008). The burden of human African trypanosomiasis. PLoS Negl. Trop. Dis., 2, e333.

Sutherland, C. S., Yukich, J., Goeree, R. & Tediosi, F. (2015). A literature review of economic evaluations for a neglected tropical disease: Human African trypanosomiasis (sleeping sickness). PLoS Negl. Trop. Dis., 9, e0003397.

WHO (2018). Trypanosomiasis, human African (sleeping sickness). Available

Simarro, P. P., Diarra, A., Ruiz, P. J. A., Franco, J. R. & Jannin, J. G. (2011). The Human African Trypanosomiasis Control and Surveillance Programme of the World Health Organization 2000–2009: the way forward. PLoS Neglected Tropical Diseases, 2011, 5, e1007 (doi:10.1371/journal.pntd.0001007).

Malvy, D. & Chappuis, F. (2011). Sleeping sickness. Clin. Microbiol. Infect., 17, 986–995.

Franco, J. R., Simarro, P. P., Diarra, A. & Jannin, J. G. (2014). Epidemiology of human African trypanosomiasis. Clin. Epidemiol., 6, 257–275.

Bern, C. (2015). Chagas’ disease. N. Engl. J. Med., 373, 456–466.

Shikanai-Yasuda, M. A. & Carvalho, N. B. (2012). Oral transmission of Chagas disease. Clin. Infect. Dis., 54, 845–852.

World Health Organization (2010). Control of the Leishmaniases. WHO Technical Report Series, 949.

Lumbala, C., Simarro, P. P., Cecchi, P. P., Paone, M., Franco, J. R., Betu Ku Mesu, V. K., Makabuza, J., Diarra, A., Chansy, S. & Priotto, G. (2015). Human African trypanosomiasis in the Democratic Republic of the Congo: Disease distribution and risk. Int. J. Health Geogr., 14, 20.

Chowdhury, R., Mondal, D., Chowdhury, V., Faria, S., Alvar, J., Nabi, S. G., Boelaert, M. & Dash, A. P. (2014). How far are we from visceral leishmaniasis elimination in Bangladesh? An assessment of epidemiological surveillance data. PLoS Negl. Trop. Dis., 8, e3020.

Picado, A., Ostyn, B., Singh, S. P., Uranw, S., Hasker, E., Rijal, S., Boelaert, M. & Chappuis, F. (2014). Risk factors for visceral leishmaniasis and asymptomatic Leishmania donovani infection in India and Nepal. PLoS ONE, 9, e87641.

Aargaard-Hasen, J., Nombela N. & Alvar, J. (2010). Population movement: a key factor in the transmission of tropical neglected diseases. Tropical Medicine and International Health, 15, 1281-1288.

Centre for Disease Control (2013). Parasites–Taeniasis available at https://www.cdc. gov/parasites/taeniasis/index.html.

Biswas, G., Sankara, D. P., Agua-Agum, J. & Maiga, A. (2013). Dracunculiasis (guinea worm disease): Eradication without a drug or a vaccine. Philos. Trans. R. Soc. B, 368, 20120146.

World Health Organization (1993). Dracunculiasis–global surveillance summary, 1992. Weekly Epidemiological Record, 68, 125–131.

Molyneux, D. & Sankara, D. P. (2017). Guinea worm eradication: Progress and challenges—should we beware of the dog? PLoS Negl. Trop. Dis., 11, e0005495.

Hopkins, D. R., Ruiz-Tiben, E., Eberhard, M. L., Roy, S. L. & Weiss, A. J. (2015). Progress toward global eradication of dracunculiasis—January 2015–June 2016. MMWR, 65, 1112–1116.

Al-Awadi, A. R., Al-Kuhlani, A., Breman, J. G., Doumbo, O., Eberhard, M. L., Guiguemde, R. T., Magnussen, P., Molyneux, D. H. & Nadim, A. (2014). Guinea worm (dracunculiasis) eradication: Update on progress and endgame challenges. Trans. R. Soc. Trop. Med. Hyg., 108, 249–251.

Centre for Disease Control (2012). Parasites–Echinococcosis available at

Budke, C., Deplazes, P. & Torgerson, P. R. (2006). Global socioeconomic impact of cystic echinococcosis. Emerging Infectious Diseases, 12, 296–302.

Torgerson, P. R., Schweiger, A., Deplazes, P., Pohar, M. & Reichen, J. (2010). The global burden of alveolar echinococcosis. PLoS Neglected Tropical Diseases, 4, e722 (doi:10.1371/journal.pntd.0000722).

Fürst, T., Keiser, J. & Utzinger, J. (2012). Global burden of human food-borne trematodiasis: a systematic review and meta-analysis. Lancet Infectious Diseases, 12, 210–221.

World Health Organization (2012). A review of human carcinogens: Biological agents. IARC Monograph on the Evaluation of Carcinogenic Risks to Humans, 100 B.

World Health Organization & World Meteorological Organization (2012). Atlas of health and climate available at /atlas/report/en/ index.html.

Pan American Health Organization (1997). Continental Plan of Expansion and Intensification to fight against Aedes aegypti: Report of a working group.

World Health Organization (2011). Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever: revised and expanded edition. New Delhi, WHO Regional Office for South-East Asia.

Murray, N. E., Quam, M. B. & Wilder-Smith, A. (2013). Epidemiology of dengue: Past, present and future prospects. Clin. Epidemiol., 5, 299–309.

Dhar-Chowdhury, P., Paul, K. K., Haque, C. E., Hossain, S., Lindsay, L. R., Dibernardo, A., Abdullah, W. & Drebot, M. A. (2017). Dengue seroprevalence, seroconversion and risk factors in Dhaka, Bangladesh. PLoS Negl. Trop. Dis., 11, e0005475.

Hampson, K., Coudeville, L., Lembo, T., Sambo, M., Kieffer, A., Attlan, M., Barrat, J., Blanton, J. D., Briggs, D. J. & Cleaveland, S. (2015). Estimating the global burden of endemic canine rabies. PLoS Negl. Trop. Dis., 9, e0003709.

Kakkar, M., Venkataramanan, V., Krishnan, S., Chauhan, R. S. & Abbas, S. S. (2012). Moving from rabies research to rabies control: Lessons from India. PLoS Negl. Trop. Dis., 6, e1748.

Devleesschauwer, B., Aryal, A., Sharma, B. K., Ale, A., Declercq, A., Depraz, S., Gaire, T. N., Gongal, G., Karki, S. & Pandey, B. D. (2016). Epidemiology, impact and control of rabies in Nepal: A systematic review. PLoS Negl. Trop. Dis., 10, e0004461.

Ramadhani, A. M., Derrick, T., Holland, M. J. & Burton, M. J. (2016). Blinding trachoma: Systematic review of rates and risk factors for progressive disease. PLoS Negl. Trop. Dis., 10, e0004859.

Emerson, P. M., Hooper, P. J. & Sarah, V. (2017). Progress and projections in the program to eliminate trachoma. PLoS Negl. Trop. Dis., 11, e0005402.

Muluneh, E. K., Zewotir, T. & Bekele, Z. (2016). Rural children active trachoma risk factors and their interactions. Pan Afr. Med. J., 24, 128.

Ngondi, J., Matthews, F., Reacher, M., Onsarigo, A., Matende, I., Baba, S., Brayne, C., Zingeser, J. & Emerson, P. (2008). Prevalence of risk factors and severity of active trachoma in southern Sudan: An ordinal analysis. Trans. R. Soc. Trop. Med. Hyg., 102, 432–438.

Ampah, K. A., Asare, P., Binnah, D. D. G., Maccaulley, S., Opare, W., Röltgen, K., Pluschke, G. & Yeboah-Manu, D. (2016). Burden and historical trend of Buruli ulcer prevalence in selected communities along the Ofï¬n River of Ghana. PloS Negl. Trop. Dis., 10, e0004603.

N’krumah, R. T. A. S., Koné, B., Tiembre, I., Cissé, G., Pluschke, G., Tanner, M. & Utzinger, J. (2016). Socio-environmental factors associated with the risk of contracting Buruli ulcer in Tiassalé, South Côte d’Ivoire: A case-control study. PLoS Negl. Trop. Dis., 10, e0004327.

Sears, A. V. & Hay, R. J. (2015). Buruli ulcer—A rapidly changing scene. Acta Derm. Venereol., 95, 387–388.

Miao, R. M. & Fieldsteel, A. H. (1980). Genetic relationship between Treponema pallidum andTreponema pertenue, two non-cultivable human pathogens. J. Bacteriol.141, 427–429.

Giacani, L. & Lukehart, S. A. (2014). The Endemic Treponematoses. Clinical Microbiology Reviews, 27 (1), 89–115. doi:10.1128/CMR.00070-13.

Marks, M., Solomon, A. W. & Mabey, D. C (2014). Endemic treponemal diseases. Transactions of the Royal Society of Tropical Medicine and Hygiene, 108 (10), 601–7. doi:10.1093/trstmh/tru128.

Mitjà , O., Šmajs, D. & Bassat, Q. (2013). Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta. PLoS Neglected Tropical Diseases, 7 (10), e2283. doi:10.1371/journal.pntd.0002283.

Perine, P. L, Hopkins, D. R., Niemel, P. L. A, St. John, R., Causse, G. & Antal, G. M. (1984). Handbook of endemic treponematoses: yaws, endemic syphilis and pina. WHO, Geneva.

World Health Organization (2012). Eradication of yaws – the Morges strategy. Weekly Epidemiological Record, 87, 189–194.

Kerr-Pontes, L., Barreto, M. L., Evangelista, C., Rodrigues, L. C., Heukelbach, J. & Feldmeier, H. (2006). Socioeconomic, environmental, and behavioural risk factors for leprosy in Northeast Brazil: Results of a case–control study. Int. J. Epidemiol., 35, 994–1000.

World Health Organization (2019). Leprosy available at

Centers for Disease Control and Prevention (2013). Lymphatic Filariasis: Epidemiology and Risk Factors available at parasites/lymphaticï¬lariasis/epi.html.

Obindo, J., Abdulmalik, J., Nwefoh, E., Agbir, M., Nwoga, C., Armiya’u, A., Davou, F., Maigida, K., Otache, E. & Ebiloma, A. (2017). Prevalence of depression and associated clinical and socio-demographic factors in people living with lymphatic ï¬lariasis in Plateau State, Nigeria. PLoS Negl. Trop. Dis., 11, e0005567.

Crump, A., Morel, C. M. & Omura, S. (2012).The onchocerciasis chronicle: from the beginning to the end? Trends in Parasitology, 28, 280–288.

Centers for Disease Control and Prevention (2013). Parasites—onchocerciasis (also known as river blindness available at epi.html.

Kim, Y. E., Remme, J. H. F., Steinmann, P., Stolk, W. A., Roungou, J. B. & Tediosi, F. (2015). Control, elimination, and eradication of river blindness: Scenarios, timelines and ivermectin treatment needs in Africa. PLoSNegl. Trop. Dis., 9, 0003664.

Kakkar, M., Venkataramanan, V., Krishnan, S., Chauhan, R. S. & Abbas, S. S. (2012). Moving from rabies research to rabies control: Lessons from India. PLoS Negl. Trop. Dis., 6, e1748.

Centers for Disease Control and Prevention (2011). The burden of schistosomiasis (schisto, bilharzia, snail fever available at diseases/schisto_burden.html.

Knowles, S. C. L. Webster, B. L., Garba, A., Sacko, M., Diaw, O. T., Fenwick, A., Rollinson, D. & Webster, J. P. (2015). Epidemiological interactions between urogenital and intestinal human schistosomiasis in the context of praziquantel treatment across three west African countries. PLoS Negl. Trop. Dis., 9, e0004019.

Adenowo, A. F., Oyinloye, B. E., Ogunyinka, B. I. & Kappo, A. P. (2015). Impact of human schistosomiasis in sub-Saharan Africa. Braz. J. Infect. Dis., 19, 196–205.

Hall, A., Hewitt, G., Tuffrey, V. & de Silva, N. (2008) A review and meta-analysis of the impact of intestinal worms on child growth and nutrition. Maternal and Child Nutrition, 4 (Suppl. 1), S118–S236.

Nokes, C., Grantham-McGregor, S. M., Sawyer, A. W., Cooper, E. S., Robinson, B. A. & Bundy, D. A. (1992). Parasitic helminth infection and cognitive function in school children. Proceedings of the Royal Society of London, 247,77–81.

Crompton, D. W. T. & Nesheim, M. C. (2002). Nutritional impact of intestinal helminthiasis during the human life cycle. Annal Review of Nutrition, 22, 35–59.

World Health Organization (2019). Soil Transmitted Helminth Infections available at

Févre, E. M., Picozzi, K., Jannin, J., Welburn, S. C. & Maudlin, I. (2006). Human African trypanosomiasis: epidemiology and control. Adv Parasitol, 61, 67-221.

World Health Organization. (‎2002)‎. Control of Chagas disease: second report of the WHO expert committee available at

Desjeux, P. (2001). The increase in risk factors for leishmaniasis worldwide. Trans R Soc Trop Med Hyg., 95, 239-43.

World Health Organization (2018). Dengue and Severe Dengue. news-room/fact-sheets/detail/dengue-and-severe-dengue

Anna, S., Fahrion, A. M., Bernadette A., Jolene, G. & Joanne, H. (2016). WHO Weekly epidemiological record, 91 (2) 13–20

World Health Organization (2018). Trachoma available at

World Health Organization (2018). Buruli ulcer (Mycobacterium ulcerans infection). Available at bacterium-ulcerans-infection).

Asiedu, K. (2008). The return of yaws. Bull World Health Organ, 86, 507-508.

Pakoa, G. (2010). Resurgence of yaws in Tanna, Vanuatu: time for a new approach? Trop Doct, 40, 68-69)

Scolnik, D., Aronson, L. & Lovinsky, R. (2003). Efficacy of a targeted, oral penicillin-based yaws control program among children living in rural South America. Clin Infect Dis, 2003, 36, 1232-1238)

Mitjà , O., Smajs, D. & Bassat, Q. (2013). Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta. PLoS Negl Trop Dis., 7, e2283.

Basáñez, M. G, Pion, S. D. S., Churcher, T. S., Breitling, L. P., Little, M. P. & Boussinesq, M. (2006). River blindness: a success story under threat? PLoS Med, 3, (9), 3371.

Steinmann, P., Keiser, J., Bos, R., Tanner, M. & Utzinger, J. (2006). Schistosomiasis and water resources development: sytematic review, meta-analysis, and estimates of people at risk. Lancet Infect Dis., 6, 411-425.

World Health Organization (2006). Global programme to eliminate lymphatic filariasis. WHO Wkly Epidemiol, 81, 22132 available at

World Health Organization (2012). Accelerating work to overcome the global impact of neglected tropical diseases: A roadmap for implementation (Executive Summary) available at pdf?ua=1.

Molyneux, D. H. (2004). Neglected†diseases but unrecognized successes–challenges and opportunities for infectious disease control. Lancet, 364, 380–383.

World Health Organization (2008) Integrated control of neglected zoonotic diseases in Africa: Applying the one health Concept available at who/htm/ntd/nzd/2008.1.

Randolph, T. F., Schelling, E., Grace, D., Nicholson, C. F., Leroy, J. L. L., Peden, D., Cole, D. C., Demment, M. W., Omore, A., Zinsstag, J. & Rue, M. T. (2007). Role of livestock in human nutrition and health for poverty reduction in developing countries. Journal of Animal Science, 85, 2788–2800.

How to Cite
Etefia, E. U. (2019). THE GLOBAL NEGELECTED TROPICAL DISEASES: THE CURRENT STATUS AND THE FUTURE PERSPECTIVE. Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315). Retrieved from