Formulation Development and In Vitro Evaluation of Levetiracetam Oral Disintegrating Tablets

  • Raghavendra Kumar Gunda Assistant Professor, Department of Pharmaceutics, M.A.M college of Pharmacy, Kesanupalli (V), Narasaraopet, Guntur (Dt), Andhra Pradesh, India-522601.
  • Prasada Rao Manchineni Professor cum Principal, Department of Pharmaceutical Analysis, M.A.M college of Pharmacy, Kesanupalli (V), Narasaraopet, Guntur (Dt), Andhra Pradesh, India-522601
  • Chaikam Gopi Reddy Research Scholars, Department of Pharmaceutics, M.A.M college of Pharmacy, Kesanupalli (V), Narasaraopet, Guntur (Dt), Andhra Pradesh, India-522601.
  • Kurapati Divya Research Scholars, Department of Pharmaceutics, M.A.M college of Pharmacy, Kesanupalli (V), Narasaraopet, Guntur (Dt), Andhra Pradesh, India-522601.
  • Duddu Alekhya Research Scholars, Department of Pharmaceutics, M.A.M college of Pharmacy, Kesanupalli (V), Narasaraopet, Guntur (Dt), Andhra Pradesh, India-522601
  • Ekula Jyoshna Research Scholars, Department of Pharmaceutics, M.A.M college of Pharmacy, Kesanupalli (V), Narasaraopet, Guntur (Dt), Andhra Pradesh, India-522601
Keywords: Levetiracetam, 32Factorial Design, super disintegrants, Crospovidone , Croscarmellose Sodium, Wetting Time, Disintegration Time, Non-Fickian Diffusion

Abstract

Objective: The main objective of current research work is to formulate the Levetiracetam oral disintegrating tablets. Levetiracetam, a newer anti convulsant and used to treat epilepsy and chronic seizures.

Methods: The oral disintegrating tablets of Levetiracetam were prepared employing various proportions of Crospovidone and Croscarmellose sodium as a Superdisintegrants by Direct Compression technique. 9 formulations were developed and are evaluated for various finished product quality assurance methods.

Results: Results reveals that all the formulation were found to be with in the Pharmacopoeial limits and  the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters were determined.

Conclusion: Formulation (F5) containing 37.5 mg of Crospovidone and 37.5 mg of Croscarmellose, is ideal formulation (similarity factor f2= 82.676, dissimilarity factor f1= 2.049 & No significant difference, t= 0.0456) to marketed product (SPRITAM-250). Formulation (F5) follows First order, Higuchi’s kinetics, mechanism of drug release was found to be Non-Fickian Diffusion (n= 0.666).

Author Biography

Raghavendra Kumar Gunda, Assistant Professor, Department of Pharmaceutics, M.A.M college of Pharmacy, Kesanupalli (V), Narasaraopet, Guntur (Dt), Andhra Pradesh, India-522601.

Raghavendra Kumar Gunda, Assistant Professor, Department of Pharmaceutics, M.A.M college of Pharmacy, Kesanupalli (V), Narasaraopet, Guntur (Dt), Andhra Pradesh, India-522601.

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Published
2019-04-19
How to Cite
Gunda, R. K., Manchineni, P. R., Reddy, C. G., Divya, K., Alekhya, D., & Jyoshna, E. (2019). Formulation Development and In Vitro Evaluation of Levetiracetam Oral Disintegrating Tablets. Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315), 8(4), 1-6. Retrieved from http://mjpms.in/index.php/mjpms/article/view/457
Section
Original Article(s)