• Aysha Arshad Delhi institute of pharmaceutical sciences and research
Keywords: Transfersomes, transdermal route, ultra deformable vesicles, stratum corneum



Objective: Transdermal drug delivery system appears to be the most vital drug delivery system because of its conveniences over already established and accepted systems. Various strategies can be used to augment the transdermal delivery which includes iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and different vesicular systems such as liposomes, niosomes, elastic liposomes such as ethosomes and transfersomes. In recent years, the vesicular systems have been encouraged as a mean of sustained or controlled release of drugs. By using the concept of rational membrane design we have recently developed special complex bodies, known as transfersomes which overcome the transportation problem.

Conclusion: Transfersomes were first introduced in the early 1990s as a form of an elastic or deformable vesicle. Elasticity is generated by incorporation of an edge activator in the lipid bilayer structure. Transfersome composed of an amphipathic ingredient such as phosphatidylcholine, other component is bilayer softening component such as a surfactant, along with lipid and surfactant, the preparation method for transfersome also alcohol as a solvent in various ratio and water or phosphate buffer solutions for hydration of vesicles. The transfersomal system was much more efficient among all these strategies. These can deform and easily pass through a narrow constriction (from 5 to 10 times less than their own diameter) without high loss of entrapped drugs. The system can be characterized by in-vitro for vesicle shape and size, entrapment efficiency, degree of deformability, number of vesicles per cubic mm and in-vitro permeability through the skin, etc. The deformability characteristic of transfersomes gives better permeation of drugs through the skin. Transfersome is pertinent in the field of insulin delivery, corticosteroid delivery, delivery of protein and peptide, also serve as a carrier for anticancer drug, anesthetics, non-steroidal anti-inflammatory drugs, and herbal drug.


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How to Cite
Arshad, A. (2019). TRANSFERSOMES: A NOVEL VESICULAR CARRIER FOR IMPROVED TRANSDERMAL DRUG DELIVERY. Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315), 5-11. Retrieved from
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