TOXIC EFFECTS OF CADMIUM AND ITS ASSOCIATION WITH IRON ON THE LIVER AND SERUM OF WISTAR RATS

  • Oluwagbenga John Ogunbiyi Department of Biochemistry, Faculty of Life Sciences, University of Benin, P.M.B 1154, Benin City, Nigeria
  • H. E IYARE
  • APATA J. T.
Keywords: Cadmium, iron, serum, liver, alanine aminotransferase and aspartate aminotransferase

Abstract

Objective: The study investigated the effect of cadmium (Cd) alone and Cd plus iron (Fe) combined on liver and serum of rats for a period of 5 weeks. Methods: Sixteen adult female rats were divided into four groups and designated as follows: Group A-control (rats exposed to exogenous Cd-free water/diet), Group B (rats exposed to Cd-tainted water/diet), Group C (rats exposed to Fe-tainted water/diet) and Group D (rats exposed to Cd and Fe-tainted water/diet). Results: At the end of 5 weeks of exposure, there was significant increase (p≤0.05) in serum cholesterol levels of rat exposed to Cd only and Fe alone relative to the control whereas a significant increase was observed in liver protein concentrations of rats exposed to Fe only when compared to the control and Cd only treated groups. The liver function test revealed increase in the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum of rats exposed to Cd only. Conclusion: The findings suggest that iron has the capacity to ameliorate and reverse cadmium induced increase in the liver enzymes assayed in the serum. The presence of iron in Cd intoxicated water or diet offer protection against cadmium induced hepatotoxicity.

 

Author Biographies

Oluwagbenga John Ogunbiyi, Department of Biochemistry, Faculty of Life Sciences, University of Benin, P.M.B 1154, Benin City, Nigeria
Research Scholar Department of Biochemistry, Faculty of Life Sciences, University of Benin, P.M.B. 1154, Benin City, Edo State, Nigeria
H. E IYARE

Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin-City

Department of Microbiology, Shakar Polytechnic, Benin-City

APATA J. T.

Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife

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Published
2019-08-14
How to Cite
Ogunbiyi, O. J., IYARE, H. E., & J. T., A. (2019). TOXIC EFFECTS OF CADMIUM AND ITS ASSOCIATION WITH IRON ON THE LIVER AND SERUM OF WISTAR RATS. Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315), 29-31. Retrieved from http://mjpms.in/index.php/mjpms/article/view/476
Section
Original Article(s)