Diabetic Nephropathy: A Curse of Diabetes

  • Raj Kumar Tiwari Columbia Institute of Pharmacy
  • Akansha Sharma Research Scholar, Columbia Institute of pharmacy, Raipur, C.G.
  • Ravindra Kumar Pandey Professor, Columbia Institute of Pharmacy, Raipur, C.G.
  • Shiv Shankar Shukla Professor, Columbia Institute of Pharmacy, Raipur, C.G.
Keywords: Pathology, RASS, Hyperlipidemia, GFR.


Diabetes associate not only rise in blood glucose level but also several diseases. One of the basic diseases is diabetic nephropathy. This is also called end stage diabetes. The various factors which are responsible for the disease are elevated metabolism, hypertension, and blockage of various molecular pathways such as AGE, RAAS, PKC, Hexsomamine and polylol. When we considered for its treatment, is associated with various multiple risk factor approach. Along with allopathic medicine herbal medicine had provided a sensible and better approach for the treatment of various kidney diseases. Effective approaches must be applied for the prevention of development Hyperlipidemia, decrease GFR and sustaini9ng the progression to later stages of nephropathy may be beneficial. This review mainly explains the pathophysiology and all the basic causes of diabetic nephropathy along with the potential herbs which may be useful for the treatment of disease.

Author Biographies

Raj Kumar Tiwari, Columbia Institute of Pharmacy

Deaprtment of Pharmacology

Asst. Professor

Akansha Sharma, Research Scholar, Columbia Institute of pharmacy, Raipur, C.G.

Department of Pharmacology, Columbia Institute of Pharmacy, Raipur, C.G.

Ravindra Kumar Pandey, Professor, Columbia Institute of Pharmacy, Raipur, C.G.

Department of Pharmacognosy, Columbia Institute of Pharmacy, Raipur, C.G.

Shiv Shankar Shukla, Professor, Columbia Institute of Pharmacy, Raipur, C.G.

Professor, Columbia Institute of Pharmacy, Raipur, C.G.


1. Hemant V., Kamble, Subhash L., Bodhankar, Trigonelline and sitagliptin attenuates nicotinamide streptozotocin induced diabetic nephropathy in wistar rats, Int J Pharm Pharm Sci, 2013; 5(4), 583-589.
2. G Kiran, CD, Nandani, HP, Ramesh, PV Salimath, Progression of early phase of diabetic nphropathy in streptozocin induces: Evaluation of various kidney related parameter, Int J Ex Bio., 2012; (50), 133-140.
3. Dewangan H, Tiwari RK, Sharma V, Shukla SS, Satapathy T, Pandey R, Past and Future of in-vitro and in-vivo Animal Models for Diabetes: A Review, Indian Journal of Pharmaceutical Education and Research, 2017; 51(4S):S522-S30.
4. Goud MB, Nayal B, Begum S, Devi SO, Bio-Chemical Aspects, Pathophysiology of Microalbuminuria and Glycated Hemoglobin in Type 2 Diabetes Mellitus, INTECH, 2012; 19-44.
5. Solini A, Dalla Vestra M, Saller A, Nosadini, R, Crepaldi G, Fioretto P, The angiotensin-converting enzyme DD genotype is associated with glomerulopathy lesions in type 2 diabetes, Diabetes, 2002; 51(1), 251-255.
6. Sharma V, Sharma PL, Role of Different Molecular Pathways in the Development of Diabetes-Induced Nephropathy, J Diabetes Metabolism, 2013; 2-7.
7. Mario BM, Amy K, David M, Douglas C, Eaton Role of the JAK/STAT signalling pathway in diabetic nephropathy, 2006 ; 762-766
8. Li Y C, Vitamin D regulation of the renin–angiotensin system. Journal of cellular biochemistry, 2003; 88(2), 327-331.
9. Fantus IG, Howard J, Goldberg, Catharine I, Whiteside D, The Hexosamine Biosynthesis Pathway, 2003; 118 -119.
10. Makhija IK, Sharma IP, Khamar D, Phytochemistry and Pharmacological properties of Ficus religiosa: an overview. Annals of Biological Research, 2010; 1(4), 171-180.
11. Mohana LS, Sandhya Rani. KS, Usha Kiran ReddyT, A Review On Diabetes Milletus And The Herbal Plants Used For Its Treatment, Asian J Pharm Clin Res, 2012; Vol 5, Issue 4, 15-21
12. Rashid, Mamun ANM, et al., A review on medicinal plants with antidiabetic activity, Journal of Pharmacognosy and Phytochemistry, 2014;3(4): 149-159
13. Jose M, Plants and their active constituents from south, central, and north america with hypoglycemic activity, 2005; 15(4): 392-413.
14. S. Elavarasi, K. Saravanan and C. Renuka 2013, A systematic review on medicinal plants used to treat diabetes mellitus 3(3), 983-992.
15. M.Uma Makheswari and D.Sudarsanam, 2012, Database on Antidiabetic indigenous plants of Tamil Nadhu, India., International Journal of Pharma Sciences and Research 3(2); 287-293.
16. Ayesha Noor1, Vinay S. Bansal1 and M. A. Vijayalakshmi, 2013, Current update on anti-diabetic biomolecules from key traditional Indian medicinal plants, 104(6): 721 -725.
17. B.Jayaprasad, D.ThamayandhI and P.S.Sharavanan, 2012, traditionally using antidiabetic medicinal plants in Tamil nadu. International Journal of Research in Pharmaceutical and Biosciences, 2(1) 1-8
18. Vidyasagar GM, Siddalinga Murthy SM, 2014, Medicinal plant used in treatment of diabetes mellitus in Bellary district, Karnataka. Indian journal of tradeitional knowledge, 12 (4): 747-751.
19. Ahmed, A. B. A., Rao, A. S., & Rao, M. V. (2010). In vitro callus and in vivo leaf extract of Gymnema sylvestre stimulate β-cells regeneration and anti-diabetic activity in Wistar rats. Phytomedicine, 17(13), 1033-1039.
20. Donga JJ, Surani VS, Sailor GU, Chauhan SP & Seth AK, 2011, A systematic review on natural medicine used for therapy of diabetes mellitus of some Indian medicinal plants, Int. J. Ph. Sci, 2 36.
21. Ghosh MN. Fundamentals of experimental Pharmacology, 3rd ed. Hilton and Company; 2005. P. 190 – 7.
22. Patel DK, Prasad SK, Kumar R, Hemalatha S, 2012, An overview on antidiabetic medicinal plant having Insulin mimetic Property, Asian Pacific Journal of Tropical Biomedicine, 320-330.
23. Babita Gupta Satish nayak and Solanki, Abroma augusta Linn f: A review, 2011, Der Pharmacia Sinica, 2 (4): 253-261.
24. B.V. Raman A. Naga Vamsi Krishna, B Narasimha Rao, M Pardha Saradhi., 2012, Plant with Antidiabetic Activities and their Medicinal Values, International Research Journal of Pharmacy, 3 (3), 11-15.
25. Maryam Rahimi, 2015, A Review: Anti Diabetic medicinal plants used for diabetes mellitus, Bull. Env. Pharmacol. Life Sci., Vol 4 [2], 163-180.
26. Kharjul Mangesh et al., 2014, Phytochemical and Pharmacological Accounts of Some Reviewed Plants with Antidiabetic Potential, Sch. Acad. J. Pharm., 3(2): 162-177
27. Ankita Bachhawat. J, Mohamed Sham Shihabudeen and Kavitha Thirumurugan, 2011, Screening of Fifteen Indian Ayurvedic Plants for Alpha-Glucosidase Inhibitory Activity and Enzyme Kinetics, 3(4): 267-274.
28. Vadi Ranjan, Manisha Vats, Neha Gupta, Satish Sardana, 2014, Antidiabetic Potential of Whole Plant of Adiantum Capillus Veneris Linn. In Streptozotocin Induced Diabetic Rats, 6(4): 341-347
29. Sheela, C. G. and Augusti, K. T., 1992, Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. Indian J. Exp. Biol., 30, 523–526.
30. Pallab Das Gupta and Amartya De., 2012, Diabetes mellitus and its herbal treatment. International Journal of Research in Pharmaceutical and Biomedical Sciences, 3 (2): 706-721.
31. Rajasekaran, S., Sivagnanam, K., Ravi, K. and Subramanian, S., 2004, Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. 7, 61–66.
32. Ghannam, N. Et al. 1986, The antidiabetic activity of aloes: Preliminary clinical and experimental observations, 24, 286–294.
33. Ukwenya V. O. et al. 2012, Antihyperglycemic activities of methanolic leaf extract of Anacardium occidentale (Linn.) on the pancreas of streptozotocin-induced diabetic rats, Journal of Cell and Animal Biology, Vol. 6(11) 169-174, June.
34. Verma V.K., Sarwa K. K. and Zaman K., 2013, Antihyperglycemic activity of Swertia Chirayita And Andrographis Paniculata Plant Extracts In Streptozotocin-Induced Diabetic Rats. Int J Pharm Pharm Sci, 5(3), 305-311.
35. H.G. Raghavendra1, Saikat Sen, 2011, Synergistic Activity Of Tribulus Terrestris And Annona Squamosa Extracts Against Alloxan Induced Diabetes And Hyperlipidemia In Rats, An International Journal Of Pharmaceutical Sciences 2 (2), 11-23.
36. Chattopadhyay, R. R et al. 1987, Preliminary report on antihyperglycemic effect of a fraction of fresh leaves of Azadirachta indica (Beng. Neem). Bull. Calcutta Sch. Trop. Med., 35, 29–35.
37. Rathod Jaimik D et al. 2011, Phytopharmacological Properties of Bambusa Arundinacea as a potential medicinal Tree: An Overview, Journal of Applied Pharmaceutical Science 01 (10); 27-31.
38. M. Salman Khan, et al. 2013, Chemotherapeutic Potential Of Boerhaavia Diffusa Linn: A Review, 3(1) : 133-139.
39. T Thirumalai, S Viviyan Therasa, EK Elumalai, E David, 2011, Hypoglycemic Effect Of Brassica Juncea (Seeds) on Streptozotocin Induced Diabetic Male Albino Rat, Asian Pac J Trop Biomed,1(4) : 311-325.
40. Namita P., Rawat M., Vijay J., 2012, Camellia Sinensis (Green Tea): A Review, Global Journal of Pharmacology, 6 (2): 52-59.
41. Patrícia L. A. Nascimento et al, 2014, Quantification, Antioxidant and Antimicrobial Activity of Phenolics Isolated From Different Extracts of Capsicum Frutescens (Pimenta Malagueta), Molecules, 19, 5434-5447.
42. Agrawal P., Singh Dk., 2014, A review on pharmacological aspects of Carum Carvi, J Biol Earth Sci, 4(1) : M1-M3.
43. Priyanga Ranasinghe1, Shehani Pigera, GA Sirimal Premakumara, Priyadarshani Galappaththy, Godwin R Constantine and Prasad Katulanda, Medicinal properties of ‘true’ cinnamon (Cinnamomum zeylanicum): a systematic review, 2013, 13:275, 3-10
44. Om Prakash, Rajesh Kumar, Ritika Srivastava, Pragya Tripathi, Shradha Mishra, Ajeet, 2015, Plants Explored with Anti-diabetic Properties: A Review, American Journal of Pharmacological Sciences, 3(3): 55-66.
45. B Deepa, C. V. Anuradha, 2011, Antidiabetic potential of Coriandrum Sativum L. Seed extract, Indian journal of experimenyal biology, 49: 30-38.
46. Mishra Shanti Bhushan et al, 2010, An analytical review of plants for anti diabetic activity with their phytoconstituent & mechanism of action, international journal of pharmaceutical sciences and research, 1(1): 29-46.
47. Graziella Ramos Rodrigues et al, 2012, Treatment with Aqueous Extract from Croton cajucara Benth Reduces Hepatic Oxidative Stress in Streptozotocin-Diabetic Rats, Journal of Biomedicine and Biotechnology, 1-7
48. N. Murugaiyan, G. Gnanamuthu, S.S. Rajendran And K. Rameshkumar, 2015, Phytochemical Screening, Antibacterial Activity And Identification of Bioactive Compound(S) In The Leaves of Bell Weed (Dipteracanthus Prostratus) For Medicinal Purpose, World Journal of Medical Sciences, 12 (3): 277-284.
49. Neeraja P.V., Elizabeth Margaret, 2012, Eclipta alba (L.) Hassk: A Valuable Medicinal herb, International Journal of Current Pharmaceutical Review and Research, 2(4); 188-197.
50. Rajamani Saranya, Thirunavukkarasu Thirumalai, Munisami Hemalatha, Ranganathan Balaji, Ernest David, 2013, Pharmacognosy of Enicostemma littorale: A review, 3(1): 79-84
51. Sharma V., R. C. Agrawal, 2013, Glycyrrhiza Glabra- A Plant for the Future, 2 (3), 15-20.
52. Amritpal Singh, Sanjiv Duggal, Navpreet Kaur, Jaswinder Singh, 2010, Berberine: Alkaloid with wide spectrum of pharmacological activities, 3: 64-75
53. Nikam Dattatrya, Mundada Shreekant, 2012, Kokilakshay- A potential Ayurvedic Herb, 3(6), 780-782.
54. Iuliana Spiridon, Constantin Bogdan Nechita, Marius Niculaua, 2013, Antioxidant and chemical properties of Inula helenium root extracts, 1699-1707

55. Barnali Gogoi, K. Zaman, 2013, Phytochemical Constituents of Some Medicinal Plant Species Used in Recipe During ‘Bohag Bihu’ in Assam, 2(2), 30-40.
56. N. C. Tanquilut1, M. R. C. Tanquilut, 2009, Hypoglycemic effect of Lagerstroemia speciosa (L.) Pers. on alloxan-induced diabetic mice, 3(12), pp. 1066-1071,
57. Dibyendu Talukdar, 2013, In Vitro Antioxidant Potential and Type II Diabetes Related Enzyme Inhibition Properties of Traditionally Processed Legume-based Food and Medicinal Recipes in Indian Himalayas, 3(1), 26-32.
58. MD. Gulshan, N. Rama Rao, 2013, An Overview on Medicinal Plants with Antidiabetic Potential, 23(2), 335-342
59. Guowen Cui 1, Longjun Jing, 2010, Anti-hyperglycemic Activity of a Polysaccharide fraction from Lycium barbarum, 13(1), 55 – 59
60. Ling Yuan1, Yi Nan, 2013, Lycium Barbarum Polysaccharides (Lbp) Extraction Technology And Its Antioxidation Activity, 7(19), 1175-1178
61. Dipesh Raj Panday, Prof. Dr. Gp Rauniar, 2014, Momordica Charantia (Karela); An Antidiabetic, 4(1), 84-99.
62. A. Chauhan, P. K. Sharma, P. Srivastava, N. Kumar, 2010, R. Dudhe, Plants Having Potential Antidiabetic Activity: A Review, 2(3):369-387
63. Yang M, et al. 1990, Effects of Ginseng Polysaccharides on Reducing Blood Glucose and Liver Glycogen, 11: 520-524.

64. Nisar Ahmad, et al. 2012, Biological role of Piper nigrum L. (Black pepper): A review, 2012, S1945-S1953
65. Anusha Bhaskar , Anish Kumar , 2012, Antihyperglycemic, antioxidant and hypolipidemic effect of Punica granatum L flower extract in streptozotocin induced diabetic rats, S1764-S1769.
66. A. A. Shetti, R. D. Sanakal and B. B. Kaliwal, 2011, Antidiabetic effect of ethanolic leaf extract of Phyllanthus amarus in alloxan induced diabetic mice, 2 (1):11-15.
67. Marisa F. Mendes1, I. David L. Bogle, 2015, Evaluation of the Effects and Mechanisms of Bioactive Components Present in Hypoglycemic Plants, International Journal of Chemical and Biomolecular Science, 1(3),167-178
68. K.G.K. Deepak, 2015, Salacia as an ayurvedic medicine with multiple targets in diabetes and obesity, Annals of Phytomedicine 4(1): 46-53.
69. V.Chitra, Venkata.K.R.Ch.H.Varma.P, M.V.R.Krishna Raju, K. Jeya Prakash, 2010, Study of Antidiabetic and Free Radical Scavenging Activity of The Seed Extract of Strychnos Nuxvomica, 2(1): 106-110.
70. P. Joshi1, and V. Dhawan, 2005, Swertia chirayita – an overview, 89(4): 635-640.
71. Sehwag Sneha, Das madhusweta, 2014, neutritive therapeutic aspects of jamun syzygium cumini (L) Skeels- An overview, Indiuan J Nat Pro Resour, . 5(4); 205-307.

72. Patience O. Osadebe, Estella U. Odoh and Philip F. Uzor, 2014, The search for new hypoglycemic agents from plants, Afr. J. Pharm. Pharmacol, 8(11), 292-303.
73. Renu Kadian1, Milind Parle, Monu Yadav, 2014, Therapeutic Potential and Phytopharmacology of Terminalia Belleric, 3(10): 804-819.
74. Suryaprakash DV, Sree Satya N, 2012, Sumanjali Avanigadda and Meena Vangalapati, Pharmacological Review On Terminalia Chebula, 3 (2): 679-683
75. H.G. Raghavendra1, Saikat Sen1, 2011, Synergistic Activity of Tribulus Terrestris and Annona Squamosa Extracts Against Alloxan Induced Diabetes and Hyperlipidemia In Rats, 2(2), 12-22.
How to Cite
Tiwari, R. K., Sharma, A., Pandey, D. R. K., & Shukla, D. S. S. (2019). A REVIEW ON MECHANISM AND PLANTS USED FOR DIABETIC NEPHROPATHY: A CURSE OF DIABETES. Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315), 5-13. Retrieved from http://mjpms.in/index.php/mjpms/article/view/481
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