PAST AND FUTURE OF PHARMACOKINETIC AND PHARMACODYNAMIC STUDY OF HERBAL DRUGS

  • Raj Kumar Tiwari Columbia Institute of Pharmacy
  • Manisha Sahu Research Scholar, Columbia Institute of Pharmacy, Raipur, C.G.
  • vikas Sharma
  • Shiv Shankar Shukla
  • ravindra Kumar Pandey
Keywords: Pharmacokinetic, Pharmacodynamic, Herbal drugs, Bioavailability, Clearance, Drug –drug interaction.

Abstract

 Aim: Plants are the most vital sources of medicines. Many people preferred plant-based medicine for the improvement of their health conditions alone or in combination with others. In recent years, more and more Pharmacokinetic (PK) & Pharmacodynamic (PD) Parameters are applicable for investigation of active components in herbal medicine.

Background: The PK parameters includes Bioavailability (Cmax, tmax, AUC), Absorption rate constant(Ka), Volume of distribution, Distribution equilibrium, Distribution rate constant, Clearance, Half-life, 1st order,0 order & mixed order kinetics, Elimination rate constant(Kel, Ka, Km ) And PD parameters includes Drug- receptor binding, Drug-drug interaction. Few research studies reported that PK & PD parameters used for herbal drugs; such as Garlic, Ginger, Curcumin, Licorice, Vinca, Emblica Officinalis, Schisandra Chinensis, Rhizoma Coptis, Pueraria lobata, Herba Ephedra, Nao-De-Sheng, Corydalis bungeana, Radix Aconiti Lateralis, Praeparata Rhubarb peony, Suan-Zao-Ren, Ginseng, Ginko, Green tea, Danshen, Ding Quai, kava, St John’s wort, Grapefruit juice, Nauclea latifolia, Echinacea purpurea and Tobacco. PK & PD study of herbal drug is mainly used for drug development, identifying drugs biological properties, determination of drug concentration in the body, drug efficacy.

Conclusion: This review discusses the past and future PK and PD studies, benefits and future studies of herbal drugs and will be helpful for young researchers who are involved in the field of herbal plants and also provide commercialization of herbal products.

Author Biographies

Raj Kumar Tiwari, Columbia Institute of Pharmacy

Deaprtment of Pharmacology

Asst. Professor

Manisha Sahu, Research Scholar, Columbia Institute of Pharmacy, Raipur, C.G.

Research Scholar, Columbia Institute of Pharmacy, Raipur, C.G.

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Published
2020-06-27
How to Cite
Tiwari, R. K., Sahu, M., Sharma, vikas, Shukla, S. S., & Pandey, ravindra K. (2020). PAST AND FUTURE OF PHARMACOKINETIC AND PHARMACODYNAMIC STUDY OF HERBAL DRUGS. Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315). Retrieved from http://mjpms.in/index.php/mjpms/article/view/505
Section
Review Article(s)