Parag Jain, Ravindra Pandey, Shiv Shankar Shukala


Ethnopharmacological relevance: Talisadya churna includes several herbal drugs which have been traditionally by ethnic groups for treating vomiting, flatulence with gurgling sound, cough, asthma, fever, anorexia, indigestion, diarrhoea, cachexia, splenic disease, malabsorption syndrome and anaemia.

Object: The present study investigated the acute and sub-acute toxicity of Talisadya churna, a polyherbal formulation, in experimental animal models.

Material and methods: In an acute toxicity study, Talisadya churna was administered orally at groups of animals of a single sex are dosed in a stepwise procedure using the fixed doses of 5, 50, 300 and 2000 mg/kg a period of at least 24 hours were allowed between the dosing of each animal and then were observed for 14 days.

Result: The results indicated there were no toxic symptoms up to the dose level of 2000 mg/kg p.o. In a subacute toxicity study, Talisadya churna was tested at different dose level of 250, 500 and 1000 mg/kg p.o. once daily for 28 days. There were no adverse effects on general condition, growth, feed and water consumption, clinical chemistry values and hematological parameters. The vital organs of animals treated with Talisadya churna for 28 days did not show any histopathological evidence of pathological lesions.

Conclusion: The result obtained in this study allowed us to conclude that the Talisadya 

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