Parikshit Kumar, S Joshi, S C Sati, D Rai


Objective: The aim of the present study was to evaluate the Ricinus communis and Thevetia peruviana for their phytochemical constituents and antibacterial activity. Methods: Successive hexane, chloroform, ethanol, methanol and aqueous plant extracts of these plants were screened for phytochemical constituents and antibacterial potential. R. communis bark and T. peruviana leaves were tested against a panel of microorganisms (Bacillus subtilis, Escherichia coli, Agrobacterium tumefaciens, Xanthomonas phaseoli and Erwinia chrysanthemi) by the disc-diffusion method. Results: Phytochemical analysis of R. communis extracts revealed the presence of saponins, phenols, flavonoids, quinines, and steroids. On the other hand, T. peruviana indicates that all extracts contained terpenoids, phenols, flavonoids, anthraquinones and free amino acids. The studied extracts of these plants displayed various degrees of antibacterial activities. The extracts of T. peruviana leaves showed the best spectra of activity against all tested microorganisms. The methanol extract was found to be most effective showing the largest zone of inhibition against A. tumefaciens (30±0.6 mm) and E. coli (28±0.3 mm). While methanolic extract of R. communis bark showed its highest inhibitory activity against B. subtilis (18±1.6 mm). The hexane extract of R. communis showed minimum antibacterial activity compared to all other extracts. Conclusion: The results of this study scientifically validate the inhibitory capacity of the above said medicinal plants attributed to their common use in folk medicine which might be useful in the development of new drugs based on natural resources.  

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