Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): GIANI MARIA CAVALCANTE, RENATA SOARES DA SILVA,KARLA MARIA SANTOS DE OLIVEIRA

Introduction: Pressure injury are susceptible to infection due to sterile loss of the innate barrier function of the skin and dermal appendages, facilitating the development of microbial communities. Objective: The aim of this study was evaluating in vitro antimicrobial activity of natural products against bacteria associated by pressure injury. Methods: The test was conducted with crude extracts of leaves and crude extracts of stem bark of vegetal species Caesalpiniaferrea and Caesalpiniapluviosa against of strains Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12228), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853), through in agar-well diffusion assay and determination of Minimal Inhibitory Concentrations (MIC). Results: The results showed that crude extract of leaves of Caesalpiniaferrea and Caesalpiniapluviosa were the most active with the diameter of inhibition zones statistically significant to all tested microorganisms, when compared with standard drug, beside that presented the best results of MIC. Conclusion: The result obtained potentiates the species Caesalpineaferrea and Caesalpineapluviosaas promising in the treatment of bacterial infections in pressure injury.