Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): Amar KumarY1*, NaveenKumar T2, LNagakrishna3

Objective:To  compare  the  local  anaesthetic  action  of  central neuron  sodium  channel blockers  Phenytoin  Sodium,  Sodium  Valproate  and  Carbamazepine  with  peripheral neuron  sodium  channel blockers Lignocaine  using Plexus  anaesthesia  in  frogs. Material  and  Methods:In  the  present  study,the  local anaesthetic effect  of  Lignocaine with concentration  of 0.2%,  0.1%  ,0.05%  was  compared with  Phenytoin  Sodium, Sodium  Valproate  and Carbamazepine  in  concentrationsof  0.2%, 0.1%  ,0.05% using different dilutions of  0.05N,0.1N,0.2N HCL  in frog plexus anaesthesia by testing foot-withdrawl reflex of the frog. Results :The results of our present study suggest onset  of local anaesthesia with lignocaine 0.2% is significantly fast when compared with concentration of 0.1%, and 0.05% indicating it has better efficacy  when  using for various   local anaesthetic  procedures. In addition onset of local anaesthesia with Phenytoin sodium concentrations of 0.2%, 0.1% ,0.05%  isfast  when compared with Sodium valproate concentrations  of  0.2%,  0.1%  ,0.05%    and    Carbamazepine  concentrations  0.2%,  0.1%  ,0.05%.   Conclusion:Among  antiepileptic  drugs  with  local  anaesthesia  and  membrane stabilizing activity Phenytoin sodium showed fast on set of action when compared with sodium valproate and carbamazepine indicating it has better efficacy