Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): SAFILA NAVEED*, HUMA DILSHADAND SAMREEN AZIZ

Atenolol is  used  in blood pressure  therapy  and available  as different   brands  in  the  market which  makes  it difficult  to  select  the  brand. The aim  of  this  study  is  to establish pharmaceutical equivalence among the differentbrands of atenolol  tablets available in Karachi, Pakistan. Four different brands of atenolol tablets (100 mg) were included in the study. Quality control analysis using parameters: weight variation test, thickness, hardness test, friability and disintegration test  were carried out specified USP and BP (United  state  and British  Pharmacopoeia).  Hardness  value  requirement was  complied by  all brands  .Disintegration  time  for all brands  was  within  15 minutes  complying  the USP/BP recommendation. All brands showed more than 90 % drug release within 45 minutes. The present analysis suggest that  all the brands of atenolol that are available  meet the BP/USP specification for quality control analysis

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