Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): RAVITEJA ACHANTA*1, PUJANITHEESHA MORAMPUDI2, DINESHBABU GOTTIPATI1, VAMSHIKRISHNA VORUGANTI1, NAGENDRARAO KUKALAKUNTA

The main objective is to formulate the buccoadhesive bilayer tablets  of thiocolchicoside which acts muscle relaxant with anti-inflammatory and analgesic effects.The tablets were prepared using bioadhesive polymers like Carbopol 934p, HPMC by direct compression method. Magnesium stearate were added to act as lubricant and ethyl cellulose used as impermeable backing layer which gives unidirectional buccal drug delivery. Buccal devices were evaluated for different parameters such as weight uniformity, content uniformity, hardness,  surface  pH,  swelling  index,  mucoadhesive  time  and  in  vitro  drug  release.  The  results  of  study  revealed  that  the formulation  containing  a  combination of  polymers  like Carbopol 934p and HPMC K4M  shows suitatble in vitro drug release. Invitro dissolution studies of the optimized formulation shows that the present drug release was 97.19% for 16 hrs for F3 formulation. Bioadhesive time, physicochemical properties, surface pH, swelling index were developed to a satisfactorylevel in terms of drug release