Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): Harshavardhan Pathapati*1, T.E. Gopala Krishna Murthy2, B. Ramanaiah3, Davu Srinivas

Objectives:Diabetes  is  a  metabolic  disorder  mainly  impairs  the  body  glucose  utilization  capacity  due  to  this  perforcely  repressingthe  immuno-dysfunction  (decreases chemotaxis, phagocytosis and intracellular killing actions) and collagen synthesis which are essential in wound debridement management of diabetic patients. Delayed wound healing is considered as one of the most repulsivedisabling and costly complication of diabetes. People with diabetes have extenuated circulation, poor resistance to infectionand  mitigate  local nutrition,  thus  their  wounds  are  meticulously  susceptible  to  infection.  Moreover  diabetes  agonizes  the  equilibrium  exists  between  accumulation  of  extra-cellular  matrix  components  and  their  re-modeling  by  matrix  metallo-proteinases  (meltrin),  due  to  this  extenuated  proliferation  action  of  fibroblasts  and  finally  freezes  the progress of wound healing frequency in hyper glycemics. However in diabetic persons the nervous system becomes numb and all feasible actions of neurons are skipped, that  condition  is  called  as  diabetic  neuropathy.  In  that  situation patient  body  features  elevated  a  glucose  level which  stiffens  thearteries  and  lack  of  pain  sensation in  foot resulting  in  commencement  of  new  wounds. Conclusion:Consider  all  problems  associated  with  wound  healing  in  diabetic  persons,  a  proper  wound  healing  management which includes controlling measures like optimized systemic and local factors as well as implement suitable wound dressing for necessary wound in diabeties patients.