Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): PRAKASH R *, BASEEM, NOWREENFATHIMA S, KARTHICK K, DEVADASS1, MURALIDHARAN. P

Objective:The  present  study  was  aimed  to  evaluate  the  central  and  peripheral  analgesic  activity  of  ethanolic  extracts  of  Hibiscus  schizopetalus  (EEHS)  (Mast)  Hook (Malvaceae) in Wistar rats. Methods:Ratsweighing about 180 to 200 g were made into 4 groups of 6 animals each. Aspirin 100mg/kg was used as standard drug. Analgesic activity wasevaluated by physical, chemical and thermal methods such as tail clip test, acetic acid induced writhing test and hot plate test at the doses 200 and 400 mg/kg of EEHSrespectively. Results:The EEHS was found to be non-toxic upto doses of 2000 mg/kg. The EEHS revealed the presence of flavonoids, alkaloids, terpenes, saponins and  glycosides  in  the  phytochemical  evaluation.  The  EEHS  treated  rats  showed  significantly  increased  basal  reaction  time  in  hot  plate  test  (p<0.001)  and  intail  clip  test (p<0.01)  respectively,  while  in  acetic  acid  method  significant  (p<0.001)  reduction  in a numberof writhingwas  observed.  The  results  were  obtained  in  a dose-dependentmanner. Conclusion:Preliminary phytochemical screening of the EEHS whichmay be responsible for analgesic activities through both by central and peripheral models