Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): J.SWATHI, K.NARENDRA,K.M SOWJANYA, A. KRISHNA SATYA

The marine environment is a tremendous source of natural products. Marine microorganisms have become an important source of pharmacologically active metabolites Fungi are well known for their vast diversity of secondary metabolites that include many life-saving drugs and highly toxic mycotoxins. In general, fungal cultures producing such metabolites are  immune  to  their  toxic  effects.  However,  some  are  known  to produce  self-toxic  compounds  that  can pose production optimization  challenges  if  the metabolites  are  needed  in large amounts for chemical modification. Objective: The main objective of the present study was the isolation of new and preferably biologically active secondary metabolites from marine microorganisms, especially marine-derived fungi. Method:Marine fungi had isolated from marine soil by serial dilution method from Rose Bengal medium. Single colony was isolated  by  microscopic  and  macroscopic  observation.  Secondary  metabolites  are  produced  by  marine  fungi.  Biological  evaluation  was  performed  by  microbial  studies.  TLC  is performed to identify the number of sub compounds in the crude extract. Further species level identification and structure elucidation of the compound are to be done. Results: The isolated marine fungi Aspergillus sp, showed maximum activity against the Candida rugosa with a zone diameter of 16mm at a concentration of 200μg and for bacterial strains it showed maximum activity against the E.coli with a diameter of 24mm at a concentration of 200μg. From the thin layer chromatography it has nearly 2-3 compounds to be purified.Conclusion: The selected organism which producesthe compounds contains the biologicalactivities which include anti-bacterial and anti fungal activitie