Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): OMEH YUSUF S1, 2*, OMOKWE K1, UGWU OKECHUKWU P.C2&ENECHIO.C

The effect of feeding Gladiolus unguiculata corm on a few liver function markers were evaluated in this study using albino Wistar rats. Twenty rats were randomly divided into four groups of five rats each. Various concentration of G. unguiculata formulations were fed to the test groups excluding thenegative control which received normal feed for the28 days of analysis. At the end of the feeding period the levels of the serum liver function markers of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP) and Protein were determined. Mean serum liver function markers were all increased when compared with the control with only AST liver marker deviating. The ALT activity increased from 36.0 + 3.16 in the control to 38.0 +3.16 in 20%. The AST significantly increased (p<0.05) from 66.0 + 3.16 in the 20% to 88.0 +3.16 in the control group. ALP significantly increased from 47.0 +3.16 in the control group to 56.0 +3.16 in 20%. Protein also increased from 7.0 +0.316in the control group to 7.8 +0.316 in 20%. The results emanating from this study suggest that Gladiolus unguiculata corm formulations might have some deleterious effects on the liver function