Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): DR. BASIM S. AHMED1, DR. SAAD H. MOHAMMED ALI 2, DR. ZAINAB A. HAMID*3,DR.ALI H. BAYATI

Background:Microbialinfections represent a major cause of miscarriage, of which viruses appear to be the most frequently involved pathogens. Among many viral causes of miscarriage, maternal infections caused by Herpes Virus type 1and 2, Cytomegalovirus (CMV) and Epstein-Barr virus infections are important causes. Among many possible causes, HLA-G was implicated in immune mechanisms, and mightbe involved, in pregnancy loss.Methods:Immunohistochemistry technique was used to detect placental infection with Herpes Virus type 1 and 2, Cytomegalovirus, and Epstein-Barr virus as well as HLAG in 40 women with spontaneous miscarriage andin 40 healthy pregnant women in Baghdad/Iraq.Results:TheHSV-1 protein was detected in(10 %) of placental tissues from miscarriage women,HSV-2 in (37.5%) , EBV-VCA in  (22.5%) , and CMV in (37.5%). The positiveHLA-G markers were detected in (55.0%) ofplacental tissues from womenwith live-bornchildren and(22.5%)  of  miscarriage placental tissues group.  The  association  between  HLAG  with  HSV-1  among  the  placental  tissues  from  miscarriage  patients  was  constituting  (5%),  (10%)  with  HSV-2,  (7.5%)  withEBV  and (2.5%)  with  CMV.Conclusion:In  conclusion,this  research  work  could  point  for an  importantrole  and participation  ofthis  marker      in  protection  the    fetuses  during succeeded  full-term  pregnancies  as  well  as  the  highest  expressions  of  HLAG  with HSV-2,lower  rates  of  each  viral  agents  especially  in  the  placental  tissues  of  healthy pregnant women than other pointing for its important protecting role