Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): Valentina Lubomirova Christova-Bagdassarian1, Kristine Samvel Bagdassarian2andMaria Stefanova Atanassova

Objective: In the present study, a comparative evaluation of the phenolic compounds antioxidant capacity and antibacterial activity toseveral kinds of seeds from the Apiacea family,  to  which  belong:  Foeniculum  vulgare  (Fennel),  Anethum  graveolens  (Dill),  Pimpinella  anisum  (Anise),  Carum  carvi  (Caraway)  and  Coriandrum  sativum  (Coriander) were carried out.Methods:The total phenolic content of seeds wasmeasured spectrophotometrically by using the Folin-Ciocalteu assay, the total flavonoids was measured spectrophotometrically by using the aluminum chloride colorimetric. Antioxidant capacity wasanalysed by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effect of the seeds and was determined also spectrophotometrically. Antibacterial activity wasanalysed by ISO standards.Results:The total phenolic and flavonoid contents of the Foeniculum vulgare (Fennel) varied between 115.96 mg GAE/100g and 68.10 mg CE/100g .The Coriandrum sativum (Coriander) content is lower (from 17.04 mg GAE/100g to  11.10  mg  CE/100g,  respecively).  The  highest  radical  scavanging  effect  was  observed  in  the  Foeniculum  vulgare  (Fennel)  withIC50  of  113.19  ml/L.  In  our  study,  themethanol extract of seeds didn’t have any antimicrobial activity.Conclusions: An original data for total phenolic and total flavonoid contents are present in this study. They are a  basis  for  assessment of  the  role of  Apiaceae  family  dry  seeds  against  free  radicals  effect  and antibacterial activity.  The  results  showthat methanolic  extract  has  the highest of total phenolic and total flavonoid contents, high potential of antioxidant activity of dry seeds from Apiaceae family, to which belong: Fennel (Foeniculum vulgare), Dill (Anethum graveolens), Anise (Pimpinella anisum), Caraway (Carum carvi) and Coriander (Coriandrum sativum). From all results, the solvent extracts of dry seeds are rich in phytochemical contents, which possessed high antioxidant and antimicrobial activities. Therefore the data found in this work might be used for further study of extracts of dry seeds from Apiaceae family on various applications such as health supplement and pharmaceutical benefits