Abstract
PREPARATION AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLETS: OF QUETIAPINE FUMARATE
Author(s): S. PRATHYUSHA1, Y. MOHAN KUMAR2, D. LAVANYA3, M. KIRAN KUMAR
The present study is performed by preparation and evaluation of floating tablets of quetiapine fumigateas model drug for prolongation of gastric residence time. Floating effervescent tablets were formulated by various materials like hydroxypropyl methylcellulose HPMC ( K4M , K100M, KE15, PLAIN ) , Sodium CMC, PVPK 30, crospovidone, Ethylcellulose, MCC, PGMS, polymerswithexcipients sodiumbicarbonate ,citric acid, lactose, magnesium stearate and talc and evaluated for floating properties, hardness, friability, dissolution, tap density and in vitro drug release studies. The gastro-retentive delivery systems of Quetiapine fumarate weresuccessfully developed in the form of hydrodynamically balanced tabletstoimprovethelocalactionanditsbioavailability,whichreducesthe wastage of drug and ultimately improves thesolubility for drugs that are less solubleinhighpHenvironment thereby improving h, the patient compliance
ISSN: 2320-3315
ICV :81.58
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Citations : 900
Mintage Journal of Pharmaceutical and Medical Sciences peer review process verified at publons
