Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): M.Pushpalatha And T.Ananthi

Ethanol extract of Solanum pubescens Linn was evaluated for hepatoprotective and antioxidant activities in rats. The plant extract (500mg/kg/day) showed a remarkable hepatoprotective and antioxidant activity against Carbon tetrachloride (CCl4)-induced hepatotoxicity as judged from the serum marker enzymes and antioxidant levels in liver tissues. CCl4induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP),total bilirubin, LPO with a reduction of total protein, superoxide dismutase (SOD), catalase, and reduced glutathione (GSH). Treatment of rats with plant extract (500 mg/kg) significantly (P<0.01) altered serum marker enzymes and antioxidant levels to near normal against CCl4-treated rats. The activity of the extract at dose of 500 mg/kg was comparable to the standard drug, Silymarin (50 mg/kg, p.o.). Histopathological examination of the liver tissues supported the hepatoprotective activity of plant.