Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): KOMAL VERMA, HARVINDER POPLI

Objective: Solid lipid nanoparticles (SLN) are rapidly developing field in nanotechnology which has several potential advantages in drug delivery, research as well as in clinical practice. They have unique properties that give them edge over other Nano-carrier systems. Method: Various research papers were reviewed and thoroughly studied from various research sites viz., PubMed, Science direct, MJPMS, etc. An attempt has been made to clarify and support why SLNs are more revolutionary method in comparison to other drug delivery systems especially in case of drugs with low bioavailability even at higher dose. Result: SLN can incorporate hydrophilic as well as hydrophobic drugs which makes it a choice of Nano-carrier over others. These nanoparticles have site-specific delivery so that it reduces the dose of a drug and causes minimum side effects. They can be incorporated in primary, secondary as well as in tertiary targeting. Conclusion: This paper reviews the advantages, disadvantages, and effects on SLN stability after PEG coating, cosmetic application of SLN & different methods of preparation which are very useful for large scale production. Additionally, it mainly focuses on the recent work that has been performed by the different researchers on SLN which include method they adopted for preparing SLN, route used for delivery of SLN, indications against which they prepare the SLN.