Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): M.Faisal Zakai, Halima Nazar, Khan Usmanghani, Sultan Ayaz

Background -Men worldwide are confronted with oligospermia which is seriously disturbing factor and requires preference of treatment. TheDepartment of Clinical Sciences, Faculty of Eastern Medicine has undertaken a task to conduct the research with Unani Medicine on clinical evaluation of male infertilityMethods -We conducted a Case control direct, uni-centre, prospective, randomized authentic herbal controlled, two arm parallel group clinical trial at multi-ceterrclinics in Karachi, Pakistan. Patients (25 years and 45 years) with clinical diagnosis of idiopathic oligospermia (n=50) were randomly assigned to receive 3gm B.D. powder of Spermogen twice a day and ProXeed B.D. twice daily. The study period was 3 years with a window for the follow up visit every month accounting for variable for semen analysis outcome measure.Results-Comparison of showed highly significant differences between test and control groups in total count of sperm and live count ofsperm (p<0.001, p<0.000) respectively. Whereas, in rapid linear progression of motility was observed equal in both treatment group (p >0.05). All these data were analyzed by Chi-square test and Fisher’s Exact Test and obtained p values and the level of significance were applied. Conclusion-Spermogen is as effective as the ProXeed in the treatment of Idiopathic of Oligospermia. There was no untoward manifestation associated with the use of Spermogen and found a good acceptability by all treated patients