Lin Ling

Department of Pulmonary and Critical Care Medicine, Second Affiliated Hospital of Fujian Medical University, China

Publications

• Research Article   
  CHARACTERIZATION OF OBESITY-ASSOCIATED LONG NONCODING RNAs IN LUNG
  Author(s): Xiaoying Fu*, Qinmiao Huang, Yancheng Lin, Lin Ling and Kuoting Ho
  
  Obesity often increases the risk of cancer and worsens the prognosis. Unlike most types of cancer, several studies concluded that obesity had an inverse influence on LUAD survival. Increasing evidence showed that obesity-related and adipocyte-derived lncRNAs were associated with cancer initiation, progression, drug resistance, and the tumour microenvironment in lung cancer. In the present study, we identified two BMI-associated lncRNAs (LINC01500 and lnc-MAFB-1) that could potentially regulate tumour progression in LUAD. Both lncRNAs downregulated significantly in the obese lung. The increased expression level of LINC01500 could be observed in LUAD tumors and predict poorer survival.In addition, through estimation from bulk RNA-seq and profiling in single-cell sequencing, we found that the expressions of both BMI-associated lncRNAs were associated with macrophages. The downregulation.. Read More»
  DOI: 10.4303/mjpms/236041

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